Heart failure with preserved ejection fraction (HFpEF) is a syndrome with high heterogeneity in pathophysiology, and its proportion in heart failure is increasing with the aging of the population. Importantly, there are few effective treatments for HFpEF, so the search for new treatments for HFpEF has become a hot topic in the current heart failure research field. In recent years, new progress has been made in the study of the pathogenesis and treatment of HFpEF, which will be reviewed in this article.