2025年4月12日 周六
Home > Archive>Volume 32, Issue 1, 2024 >87-92
PDF HTML XML Export Cite reminder
Research progress of T-cadherin in coronary heart disease
CSTR:
[cstr]
Author:
Affiliation:

1.College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;2.Hunan University of Chinese Medicine & Hunan Provincial Key Laboratory of TCM Diagnositics, Changsha, Hunan 410208, China;3.Traditional Chinese Medicine Hospital of Sangzhi County, Zhangjiajie, Hunan 427000, China)

Clc Number:

R5

  • Article
    • | |
  • Metrics
    • |
  • Reference [52]
    • |
  • Related [20]
    • | | |
  • Comments
    Abstract:

    T-cadherin (T-cad) is a newly discovered adiponectin receptor, which can bind to adiponectin hexamer and high molecular weight polymer. T-cad is widely expressed in many tissues in vivo, especially in the cardiovascular system. T-cad is closely related to coronary heart disease, and has the effects of inhibiting cell apoptosis, preventing atherosclerosis, limiting vascular intimal hyperplasia, inducing vascular endothelial cell proliferation, promoting the secretion of growth factors, and promoting muscle regeneration. Therefore, exploring the mechanism of T-cad in coronary heart disease may provide new ideas for the diagnosis and treatment of coronary heart disease.

    Reference
    [1] 北京高血压防治协会, 北京糖尿病防治协会, 北京慢性病防治与健康教育研究会, 等.基层心血管病综合管理实践指南2020.中国医学前沿杂志(电子版), 0,2(8):1-73.Beijing Hypertension Prevention and Treatment Association, Beijing Diabetes Prevention and Treatment Association, Beijing Chronic Disease Prevention and Health Education Research Association, et al.Practise guideline (2020) for integrated management of cardiovascular diseases in primary hospitals.Chin J Front Med Sci (Electronic Version), 0,2(8):1-73.
    [2] 乔莞宁, 陈虹印, 张扬.氧化应激与动脉粥样硬化.中国动脉硬化杂志, 3,1(4):312-321.QIAO G N, CHEN H Y, ZHANG Y.Oxidative stress and atherosclerosis.Chin J Arterioscler, 3,1(4):312-321.
    [3] BALATSKIY A, TETERINA M, PISARYUK A, et al.T-cadherin and the ratio of its ligands as predictors of carotid atherosclerosis:a pilot study.Biomedicines, 1,9(10):1398.
    [4] DROUET L, BAL DIT SOLLIER C.Fibrinogen:factor and marker of cardiovascular risk.J Mal Vasc, 2,7(3):143-156.
    [5] TKACHUK V A, BOCHKOV V N, PHILIPPOVA M P, et al.Identification of an atypical lipoprotein-binding protein from human aortic smooth muscle as T-cadherin.FEBS Lett, 8,1(3):208-212.
    [6] KIPMEN-KORGUN D, OSIBOW K, ZORATTI C, et al.T-cadherin mediates low-density lipoprotein-initiated cell proliferation via the Ca2＋-tyrosine kinase-Erk1/2 pathway.J Cardiovasc Pharmacol, 5,5(5):418-430.
    [7] IVANOV D, PHILIPPOVA M, ANTROPOVA J, et al.Expression of cell adhesion molecule T-cadherin in the human vasculature.Histochem Cell Biol, 1,5(3):231-242.
    [8] SIMONNEAU L, GALLEGO M, PUJOL R.Comparative expression patterns of T-, N-, E-cadherins, β-catenin, and polysialic acid neural cell adhesion molecule in rat cochlea during development:implications for the nature of Klliker's organ.J Comp Neurol, 3,9(2):113-126.
    [9] 黄志勇, 罗钒, 陈孝平, 等.黏附分子T-cadherin表达对C6细胞恶性特性的影响.中华实验外科杂志, 5,2(10):1205-1206.HUANG Z Y, LUO F, CHEN X P, et al.Effect of T-cadherin gene expression on malignant biological characteristics in C6 glioma cells.Chin J Exp Surg, 5,2(10):1205-1206.
    [10] VESTAL D J, RANSCHT B.Glycosyl phosphatidylinositol-anchored T-cadherin mediates calcium-dependent, homophilic cell adhesion.J Cell Biol, 2,9(2):451-461.
    [11] PHILIPPOVA M, IVANOV D, TKACHUK V, et al.Polarisation of T-cadherin to the leading edge of migrating vascular cells in vitro:a function in vascular cell motility?.Histochem Cell Biol, 3,0(5):353-360.
    [12] 马林, 陈旭, 邵明燕, 等.脂联素介导的AMPK通路在冠心病脂质代谢中的分子调控机制及中医药研究进展.中西医结合心脑血管病杂志, 0,8(14):2248-2251.MA L, CHEN X, SHAO M Y, et al.The molecular regulatory mechanism of adiponectin mediated AMPK pathway in lipid metabolism of coronary heart disease and research progress in traditional Chinese medicine.Chin J Integr Med Cardio-Cerebrovasc Dis, 0,8(14):2248-2251.
    [13] 李涵, 黄宇鹏, 金红艳, 等.外周血APN、HbA1c、糖基化ApoA-I水平与冠心病患者PCI术后血运重建的关系.解放军医药杂志, 1,3(9):58-1,8.LI H, HUANG Y P, JIN H Y, et al.Correlations between peripheral blood levels of APN, HbA1c and glycosylated ApoA-I with revascularization in patients with coronary heart disease after PCI.Med Pharm J CPLA, 1,3(9):58-1,8.
    [14] 向晓华.桂北地区人群脂联素及其受体基因多态性与冠心病易感性研究.桂林:桂林医学院, 2021:1-49.XIANG X H.Association of adiponectin and its receptor gene polymorphisms with susceptibility to coronary heart disease in Northern Guangxi, China.Guilin:Guilin Medical University, 2021:1-49.
    [15] ERNST E, RESCH K L.Fibrinogen as a cardiovascular risk factor:a Meta-analysis and review of the literature.Ann Intern Med, 3,8(12):956-963.
    [16] HUG C, WANG J, AHMAD N S, et al.T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin.Proc Natl Acad Sci U S A, 4,1(28):10308-10313.
    [17] PASCOLUTTI R, ERLANDSON S C, BURRI D J, et al.Mapping and engineering the interaction between adiponectin and T-cadherin.J Biol Chem, 0,5(9):2749-2759.
    [18] OBATA Y, KITA S, KOYAMA Y, et al.Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release.JCI Insight, 8,3(8):e99680.
    [19] 王敏.脂联素对心肌细胞缺氧/复氧损伤后AdipoR1、AdipoR2及T-cadherin表达的影响.太原:山西医科大学, 2012:10-19.WANG M.Effects of adiponectin on the expressions of AdipoR1、AdipoR2 and T-cadherin in cardiomyocytes injure after hypoxia-reoxygenation.Taiyuan:Shanxi Medical University, 2012:10-19.
    [20] 易敏, 戴幸平, 李秋霞, 等.基于1H-NMR的冠心病血瘀证、痰浊证的代谢组学研究.中南大学学报(医学版), 1,6(6):591-600.YI M, DAI X P, LI Q X, et al.1H-NMR-based metabolomics study on coronary heart disease with blood-stasis syndrome and phlegm syndrome.J Cent South Univ (Med Sci), 1,6(6):591-600.
    [21] MATAFOME P, RODRIGUES T, PEREIRA A, et al.Long-term globular adiponectin administration improves adipose tissue dysmetabolism in high-fat diet-fed Wistar rats.Arch Physiol Biochem, 4,0(4):147-157.
    [22] HOLLAND W L, XIA J Y, JOHNSON J A, et al.Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis.Mol Metab, 7,6(3):267-275.
    [23] VASILIAUSKAIT-BROOKS I, SOUNIER R, ROCHAIX P, et al.Structural insights into adiponectin receptors suggest ceramidase activity.Nature, 7,4(7648):120-123.
    [24] STAIGER H, TSCHRITTER O, MACHANN J, et al.Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans.Obes Res, 3,1(3):368-372.
    [25] ZIETZ B, HERFARTH H, PAUL G, et al.Adiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetes.FEBS Lett, 3,5(2/3):103-104.
    [26] KUDRJASHOVA E, BASHTRIKOV P, BOCHKOV V, et al.Expression of adhesion molecule T-cadherin is increased during neointima formation in experimental restenosis.Histochem Cell Biol, 2,8(4):281-290.
    [27] LAU W B, OHASHI K, WANG Y J, et al.Role of adipokines in cardiovascular disease.Circ J, 7,1(7):920-928.
    [28] BORUTAITE V, BUDRIUNAITE A, MORKUNIENE R, et al.Release of mitochondrial cytochrome c and activation of cytosolic caspases induced by myocardial ischaemia.Biochim Biophys Acta, 1,7(2):101-109.
    [29] 杨胜利, 何作云, 冯兵.细胞凋亡与冠心病.中国动脉硬化杂志, 3,1(4):379-381.YANG S L, HE Z Y, FENG B.Apoptosis and coronary heart disease.Chin J Arterioscler, 3,1(4):379-381.
    [30] 黄辉, 刘坪, 蔺鹏阳, 等.苯甲酰芍药苷影响冠状动脉粥样硬化性心脏病模型大鼠心肌细胞凋亡的机制研究.中华老年心脑血管病杂志, 0,2(8):862-865.HUANG H, LIU P, LIN P Y, et al.Mechanism of benzoylpaeoniflorin underlying apoptosis of myocardial cells in a atherosclerotic coronary heart disease model of rats.Chin J Geriatr Heart Brain Ves Dis, 0,2(8):862-865.
    [31] ZHANG L J, ZENG X T, ZHAO M J, et al.The important effect of 5-HTTLPR polymorphism on the risk of depression in patients with coronary heart disease:a Meta-analysis.BMC Cardiovasc Disord, 0,0(1):141.
    [32] ZHANG Y, ZHAO H R, LIU B, et al.Low level antibodies against alpha-tropomyosin are associated with increased risk of coronary heart disease.Front Pharmacol, 0,1:195.
    [33] JOSHI M B, PHILIPPOVA M, IVANOV D, et al.T-cadherin protects endothelial cells from oxidative stress-induced apoptosis.FASEB J, 5,9(12):1737-1739.
    [34] PHILIPPOVA M, BANFI A, IVANOV D, et al.Atypical GPI-anchored T-cadherin stimulates angiogenesis in vitro and in vivo.Arterioscler Thromb Vasc Biol, 6,6(10):2222-2230.
    [35] 李艳芳, 田红梅, 李红燕.内皮细胞特异性分子1与冠心病大鼠主动脉内皮细胞炎性损伤和血管重构的关系.中华老年心脑血管病杂志, 3,5(3):293-297.LI Y F, TIAN H M, LI H Y.Relationship of endocan with inflammatory injury and vascular remodeling of aortic endothelial cells in CHD rats.Chin J Geriatr Heart Brain Ves Dis, 3,5(3):293-297.
    [36] DAVIES M J.Stability and instability:two faces of coronary atherosclerosis.The Paul Dudley White Lecture 1995.Circulation, 6,4(8):2013-2020.
    [37] 王旭, 于鲁, 李珠, 等.通脉养心方及其化学成分治疗心肌缺血/再灌注损伤的作用机制研究进展.中草药, 3,4(9):3012-3021.WANG X, YU L, LI Z, et al.Research progress on mechanism of Tongmai Yangxin recipe and its chemical components in treatment of myocardial ischemia/reperfusion injury.Chin Tradit Herbal Drugs, 3,4(9):3012-3021.
    [38] WYDER L, VITALITI A, SCHNEIDER H, et al.Increased expression of H/T-cadherin in tumor-penetrating blood vessels.Cancer Res, 0,0(17):4682-4688.
    [39] IVANOV D, PHILIPPOVA M, ALLENSPACH R, et al.T-cadherin upregulation correlates with cell-cycle progression and promotes proliferation of vascular cells.Cardiovasc Res, 4,4(1):132-143.
    [40] 陈颖弘, 李倩, 吴学铭, 等.细胞焦亡与血管重塑相关疾病的研究进展.重庆医学, 2,1(20):3564-3568.CHEN Y H, LI Q, WU X M, et al.Research advances of pyroptosis and vascular remodeling related diseases.Chongqing Med, 2,1(20):3564-3568.
    [41] PHILIPPOVA M P, BOCHKOV V N, STAMBOLSKY D V, et al.T-cadherin and signal-transducing molecules co-localize in caveolin-rich membrane domains of vascular smooth muscle cells.FEBS Lett, 8,9(2):207-210.
    [42] KUBOTA N, YANO W, KUBOTA T, et al.Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake.Cell Metab, 7,6(1):55-68.
    [43] GAO C, LIU Y, YU Q J, et al.TNF-α antagonism ameliorates myocardial ischemia-reperfusion injury in mice by upregulating adiponectin.Am J Physiol Heart Circ Physiol, 5,8(12):H1583-H1591.
    [44] TANAKA Y, KITA S, NISHIZAWA H, et al.Adiponectin promotes muscle regeneration through binding to T-cadherin.Sci Rep, 9,9(1):16.
    [45] 伊加提·司马义, 帕合热丁·努尔麦麦提, 阿布都乃比·麦麦提艾力.辅酶Q10对冠心病心肌缺血再灌注损伤大鼠心肌细胞凋亡的影响.中西医结合心脑血管病杂志, 2,0(10):1760-1765.SIMAYI Y J T, NUERMAIMAITI P H R D, MAIMAITIAILI A B D N B.Effect of coenzyme Q10 on apoptosis of myocardial cells during myocardial ischemia-reperfusion injury in rats with coronary heart disease.Chin J Integr Med Cardio/Cerebrovasc Dis, 2,0(10):1760-1765.
    [46] DENZEL M S, SCIMIA M C, ZUMSTEIN P M, et al.T-cadherin is critical for adiponectin-mediated cardioprotection in mice.J Clin Invest, 0,0(12):4342-4352.
    [47] 周允, 卢丽霞, 魏利龙, 等.冠心病患者四种常规炎症标志物联合检测对急性心肌梗死的预测价值.中国动脉硬化杂志, 3,1(4):297-303.ZHOU Y, LU L X, WEI L L, et al.Predictive value of combined detection of four conventional inflammatory markers for acute myocardial infarction in patients with coronary heart disease.Chin J Arterioscler, 3,1(4):297-303.
    [48] 王娟娟.脂联素受体T-钙黏蛋白在急性心肌梗死中的表达及与急性炎症反应关联性研究.呼和浩特:内蒙古医科大学, 2019:26-29.WANG J J.Expression of adiponectin receptor T-cadherin in acute myocardial infarction and its association with acute inflammatory reaction.Hohhot:Inner Mongolia Medical University, 2019:26-29.
    [49] IIOKA M, FUKUDA S, MAEDA N, et al.Time-series change of serum soluble T-cadherin concentrations and its association with creatine kinase-MB levels in ST-segment elevation myocardial infarction.J Atheroscler Thromb, 2,9(12):1823-1834.
    [50] 朱毅.低密度脂蛋白诱导的血管内皮激活中的信号转导//国际心脏研究会中国分会第八届学术会议暨中国病理生理学会心血管专业委员会第十一届学术会议论文摘要集.广州:暨南大学, 2004:25-26.ZHU Y.Signal transduction in vascular endothelial activation induced by low-density lipoprotein//Abstract Collection of Papers from the 8th Academic Conference of the Chinese Branch of the International Heart Research Association and the 11th Academic Conference of the Cardiovascular Professional Committee of the Chinese Society of Pathology and Physiology.Guangzhou:Jinan University, 2004:25-26.
    [51] KUZMENKO Y S, BOCHKOV V N, PHILIPPOVA M P, et al.Characterization of an atypical lipoprotein-binding protein in human aortic media membranes by ligand blotting.Biochem J, 4,3(Pt 1):281-287.
    [52] RESINK T J, KUZMENKO Y S, KERN F, et al.LDL binds to surface-expressed human T-cadherin in transfected HEK293 cells and influences homophilic adhesive interactions.FEBS Lett, 9,3(1/2):29-34.
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

ZHAO Yanzhen, JIAN Weixiong, ZHONG Yin. Research progress of T-cadherin in coronary heart disease[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(1):87-92.

Copy
Share
Article Metrics
  • Abstract:190
  • PDF: 644
  • HTML: 0
  • Cited by: 0
History
  • Received:March 25,2023
  • Revised:May 07,2023
  • Online: February 05,2024
Article QR Code

You are the 30663 visitor

Post Code：421001 Fax：0734-8160523

Phone：0734-8160765 E-mail：dmzzbjb@163.net

Editorial Office of Chinese Journal of Arteriosclerosis ® 2025