Brain abundant membrane attached signal protein 1 (BASP1) was first discovered in the rat brain and is primarily enriched in brain, heart, mouth, skin, stomach, kidneys and many other human organs. The BASP1 protein is evolutionarily conserved. It participates in cellular biological processes such as cell signaling, cell migration, apoptosis, and gene transcription as an inherently disordered protein (IDP), and is involved in a series of pathophysiological processes such as neural development, kidney development, and germ cell formation. BASP1 plays a very important function in glucose, lipid metabolism diseases and tumor diseases, and is considered to be a potential disease treatment target and molecular diagnostic marker.