Calcific aortic valve disease (CAVD) is the most common disease affecting the heart valves, characterized by thickening, fibrosis, and mineralization of the aortic valve leaflets. Currently, there is no effective pharmacological treatment. Aortic valve calcification is a complex and multifactorial process involving valve inflammation, fibrosis, calcification, valve thickening and outflow tract obstruction. The exact pathophysiological mechanisms of CAVD are not fully understood, but many studies have suggested that innate immune cells play a key role in the development of aortic valve calcification. This review focuses on the current role of innate immune cells in the development of CAVD.