Research progress in the role of m<sup>6</sup>A methylation in the pathogenesis of myocardial remodeling after myocardial infarction

doi:10.20039/j.cnki.10073949.2024.07.009.

Home > Archive>Volume 32, Issue 7, 2024 >613-620. DOI:10.20039/j.cnki.10073949.2024.07.009.

Research progress in the role of m6A methylation in the pathogenesis of myocardial remodeling after myocardial infarction
DOI:
                        10.20039/j.cnki.10073949.2024.07.009.
                    
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                        XIE Changxu1,2XIE Changxu
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China
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GUO Shuaijie1,2GUO Shuaijie
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China
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CHEN Siqi1,2CHEN Siqi
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China
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ZHANG Lei1,2ZHANG Lei
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China
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LIU Weihong1,2LIU Weihong
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China
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LI Sinai1,2LI Sinai
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China
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ZHOU Mingxue1,2ZHOU Mingxue
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China
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Affiliation:1.Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;2.Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China)
Clc Number:R363;R5
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Abstract:

Myocardial infarction is the most common cause of heart failure, and myocardial remodeling can occur after infarction, thus contributing to the progression of heart failure. The occurrence of post-infarction ventricular remodeling is closely related to m⁶A methylation. m⁶A methylation is a reversible and highly dynamic process. This process is mainly mediated by m⁶A methylation positive and negative regulatory enzymes and is involved in the occurrence of post-infarction myocardial remodeling through mechanisms such as cellular autophagy. This article mainly reviews relevant literature in recent years. Firstly, a brief introduction is given to m⁶A methylation, followed by an introduction to the role of m⁶A methylase in regulating myocardial remodeling. Finally, a summary analysis is conducted on the mechanism of m⁶A methylation in regulating myocardial remodeling from the perspectives of autophagy, inflammation, cell apoptosis, calcium ion homeostasis, extracellular matrix remodeling, and ferroptosis. The feasibility of using m⁶A methylation serological detection as a diagnostic tool for myocardial remodeling after myocardial infarction is discussed, in order to provide reference for related research.

Key words:m⁶A methylation; myocardial infarction; myocardial remodeling; heart failure

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XIE Changxu, GUO Shuaijie, CHEN Siqi, ZHANG Lei, LIU Weihong, LI Sinai, ZHOU Mingxue. Research progress in the role of m⁶A methylation in the pathogenesis of myocardial remodeling after myocardial infarction[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(7):613-620.

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Received:June 25,2023
Revised:September 01,2023
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Online: July 05,2024
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