HDAC3:a new target for atherosclerosis therapy

doi:10.20039/j.cnki.10073949.2024.07.010.

Home > Archive>Volume 32, Issue 7, 2024 >621-626, 640. DOI:10.20039/j.cnki.10073949.2024.07.010.

HDAC3:a new target for atherosclerosis therapy
DOI:
                        10.20039/j.cnki.10073949.2024.07.010.
                    
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                        XIA Zihan1,2XIA Zihan
Department of Laboratory Animal Science, School of Basic Medical Science, ;Institute of Cardiovascular Science, Translational Medicine Institute, Xian Jiaotong University, Health Science Center, Xian, Shaanxi 710061, China
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ZHANG He1,2ZHANG He
Department of Laboratory Animal Science, School of Basic Medical Science, ;Institute of Cardiovascular Science, Translational Medicine Institute, Xian Jiaotong University, Health Science Center, Xian, Shaanxi 710061, China
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ZHANG Ziqiong1,2ZHANG Ziqiong
Department of Laboratory Animal Science, School of Basic Medical Science, ;Institute of Cardiovascular Science, Translational Medicine Institute, Xian Jiaotong University, Health Science Center, Xian, Shaanxi 710061, China
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LI Xingyi1,2LI Xingyi
Department of Laboratory Animal Science, School of Basic Medical Science, ;Institute of Cardiovascular Science, Translational Medicine Institute, Xian Jiaotong University, Health Science Center, Xian, Shaanxi 710061, China
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WANG Yining1,2WANG Yining
Department of Laboratory Animal Science, School of Basic Medical Science, ;Institute of Cardiovascular Science, Translational Medicine Institute, Xian Jiaotong University, Health Science Center, Xian, Shaanxi 710061, China
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WANG Weirong1,2WANG Weirong
Department of Laboratory Animal Science, School of Basic Medical Science, ;Institute of Cardiovascular Science, Translational Medicine Institute, Xian Jiaotong University, Health Science Center, Xian, Shaanxi 710061, China
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Affiliation:1.Department of Laboratory Animal Science, School of Basic Medical Science, ;2.Institute of Cardiovascular Science, Translational Medicine Institute, Xi'an Jiaotong University, Health Science Center, Xi'an, Shaanxi 710061, China)
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Abstract:

Histone deacetylase 3 (HDAC3) is an epigenetic modification enzyme, which participates in the occurrence and development of atherosclerosis (As). It is significant to search for effective HDAC3 inhibitors for the treatment of atherosclerosis. This article reviews the relationship between HDAC3 and atherosclerosis, the latest research progress of HDAC3 inhibitors, and the therapeutic effects of some traditional Chinese medicine on cardiovascular diseases by inhibiting HDAC3. It aims to provide new ideas for developing anti-atherosclerotic drugs targeting HDAC3.

Key words:histone deacetylase 3; atherosclerosis; inhibitors; traditional Chinese medicine

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XIA Zihan, ZHANG He, ZHANG Ziqiong, LI Xingyi, WANG Yining, WANG Weirong. HDAC3:a new target for atherosclerosis therapy[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(7):621-626, 640.

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Received:September 05,2023
Revised:October 23,2023
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Online: July 05,2024
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