Research progress and current status of circular RNA in heart failure

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Research progress and current status of circular RNA in heart failure
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                        YANG Qin1YANG Qin
Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China
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DU Bingxin1DU Bingxin
Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China
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YANG Yeying1YANG Yeying
Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China
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LI Rui1LI Rui
Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China
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TIAN Jinwei2,3TIAN Jinwei
Heilongjiang Provincial Key Laboratory of Panvascular Disease, Harbin, Heilongjiang 150086, China;Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China
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LIU Huibin1,2LIU Huibin
Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China;Heilongjiang Provincial Key Laboratory of Panvascular Disease, Harbin, Heilongjiang 150086, China
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Affiliation:1.Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China;2.Heilongjiang Provincial Key Laboratory of Panvascular Disease, Harbin, Heilongjiang 150086, China;3.Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China)
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Abstract:

Circular RNA (circRNA) is a novel class of endogenous non-coding RNA with complex biological functions, participating in various physiological and pathological processes. Due to their relatively stable stucture and tissue-specific and temporal expression patterns, circRNA have become a recent focus of biomedical research. Heart failure (HF) is characterized by impaired ventricular filling and/or ejection function caused by primary myocardial injury and cardiac overload, leading to the inability of the heart to meet the metabolic demands of the body’s tissues. It is the end stage of numerous cardiac diseases. Studies have found that circRNA may play a crucial regulatory role in the progression of HF, particularly in cardiomyocyte hypertrophy, cardiomyocyte apoptosis, autophagy and myocardial fibrosis. This review summarizes the formation, classification, functional forms, and roles in HF of circRNA, aiming to provide new insights for the prevention and treatment of HF.

Key words:circular RNA; heart failure; myocardial fibrosis; cardiomyocyte hypertrophy; apoptosis; autophagy

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YANG Qin, DU Bingxin, YANG Yeying, LI Rui, TIAN Jinwei, LIU Huibin. Research progress and current status of circular RNA in heart failure[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(9):737-746.

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Received:April 11,2024
Revised:May 21,2024
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Online: September 30,2024
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