2025年4月6日 周日
Home > Archive>Volume 32, Issue 10, 2024 >916-920
PDF HTML XML Export Cite reminder
Endothelial cell senescence and vascular dysfunction
Author:
Affiliation:

1.Institute of Cardiovascular Disease, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province,Hengyang, Hunan 421001, China;2.University of South China, Hengyang, Hunan 421001, China)

Clc Number:

R5;R363

  • Article
    • | |
  • Metrics
    • |
  • Reference [37]
    • |
  • Related [20]
    • | | |
  • Comments
    Abstract:

    Endothelial cell senescence is increasingly recognized as an important factor in the development of vascular dysfunction and age-related diseases. As is well known, the occurrence of endothelial cell senescence involves multiple factors, and endothelial cell senescence and vascular dysfunction interact with each other. This review summarized the phenotypic changes of endothelial cell senescence, and reviewed the relationship between endothelial cell senescence and various vascular dysfunction, such as dysfunction of vascular relaxation and contraction, impaired vascular barrier function, and vasculitis. The aim is to provide reference for delaying human vascular aging and improving vascular function.

    Reference
    [1] GIACOMELLO E, TONIOLO L.Nutrition, diet and healthy aging.Nutr, 2,4(1):190.
    [2] 张瑜, 涂均楚, 李玉洁, 等.动脉粥样硬化危险因素衰老、肥胖、生物钟紊乱与核糖体新生的研究进展.中国动脉硬化杂志, 3,1(11):921-928.ZHANG Y, TU J C, LI Y J, et al.Research progress of atherosclerosis risk factors like aging, obesity, circadian clock disorders and ribosome biogenesis.Chin J Arterioscler, 3,1(11):921-928.
    [3] WU Y Y, HIRSCHI K K.Regulation of hemogenic endothelial cell development and function.Annu Rev Physiol, 1,3:17-37.
    [4] YUAN W, XIA H, XU Y, et al.The role of ferroptosis in endothelial cell dysfunction.Cell Cycle, 2,1(18):1897-1914.
    [5] ROGER L, TOMAS F, GIRE V.Mechanisms and regulation of cellular senescence.Int J Mol Sci, 1,2(23):13173.
    [6] JIMENEZ TRINIDAD F R, ARRIETA RUIZ M, SOLANES BATLL N, et al.Linking in vitro models of endothelial dysfunction with cell senescence.Life, 1,1(12):1323.
    [7] MCGLYNN L M, STEVENSON K, LAMB K, et al.Cellular senescence in pretransplant renal biopsies predicts postoperative organ function.Aging Cell, 9,8(1):45-51.
    [8] YIN H, PICKERING J G.Cellular senescence and vascular disease:novel routes to better understanding and therapy.Can J Cardiol, 6,2(5):612-623.
    [9] RYU S J, OH Y S, PARK S C.Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts.Cell Death Differ, 7,4(5):1020-1028.
    [10] CENCIONI C, SPALLOTTA F, MARTELLI F, et al.Oxidative stress and epigenetic regulation in ageing and age-related diseases.Int J Mol Sci, 3,4(9):17643-17663.
    [11] MARTNEZ-ZAMUDIO R I, ROBINSON L, ROUX P F, et al.SnapShot:cellular senescence pathways.Cell, 7,0(4):816-816.e1.
    [12] MOHAMAD KAMAL N S, SAFUAN S, SHAMSUDDIN S, et al.Aging of the cells:insight into cellular senescence and detection Methods.Eur J Cell Biol, 0,9(6):151108.
    [13] HERNANDEZ-SEGURA A, NEHME J, DEMARIA M.Hallmarks of cellular senescence.Trends Cell Biol, 8,8(6):436-453.
    [14] LEE G H, HOANG T H, JUNG E S, et al.Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats.Aging Cell, 0,9(12):e13279.
    [15] LEVINE Y C, LI G K, MICHEL T.Agonist-modulated regulation of AMP-activated protein kinase(AMPK)in endothelial cells.Evidence for an AMPK->Rac1->Akt-> endothelial nitric-oxide synthase pathway.J Biol Chem, 7,2(28):20351-20364.
    [16] LI R X, MI X N, YANG S J, et al.Long-term stimulation of angiotensinⅡ induced endothelial senescence and dysfunction.Exp Gerontol, 9,9:212-220.
    [17] PARK K, LI Q, LYNES M D, et al.Endothelial cells induced progenitors into brown fat to reduce atherosclerosis.Circ Res, 2,1(2):168-183.
    [18] FLAVAHAN S, CHANG F M, FLAVAHAN N A.Local renin-angiotensin system mediates endothelial dilator dysfunction in aging arteries.Am J Physiol Heart Circ Physiol, 6,1(3):H849-H854.
    [19] SHAN H Y, ZHANG S Y, LI X L, et al.Valsartan ameliorates ageing-induced aorta degeneration via angiotensinⅡ type 1 receptor-mediated ERK activity.J Cell Mol Med, 4,8(6):1071-1080.
    [20] BLOOM S I, ISLAM M T, LESNIEWSKI L A, et al.Mechanisms and consequences of endothelial cell senescence.Nat Rev Cardiol, 3,0(1):38-51.
    [21] LI C Z, SHEN Y T, HUANG L W, et al.Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence.FASEB J, 1,5(1):e21229.
    [22] DAZ-VESGA M C, ZU＇IGA-CUEVAS U＇, RAMREZ-REYES A, et al.Potential therapies to protect the aging heart against ischemia/reperfusion injury.Front Cardiovasc Med, 1,8:770421.
    [23] GROOTAERT M O J, FINIGAN A, FIGG N L, et al.SIRT6 protects smooth muscle cells from senescence and reduces atherosclerosis.Circ Res, 1,8(4):474-491.
    [24] BU L L, YUAN H H, XIE L L, et al.New dawn for atherosclerosis:vascular endothelial cell senescence and death.Int J Mol Sci, 3,4(20):15160.
    [25] WANG L, MAO B, FAN K Y, et al.ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells.Fluids Barriers CNS, 2,9(1):73.
    [26] FAN X S, YANG Y, QI L.Vildagliptin protects hypoxia/reoxygenation-induced injury of cardiac microvascular endothelial cells.Minerva Med, 3,4(2):210-216.
    [27] UNGVARI Z, TARANTINI S, DONATO A J, et al.Mechanisms of vascular aging.Circ Res, 8,3(7):849-867.
    [28] TAI S, SUN J X, ZHOU Y Y, et al.Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux.J Adv Res, 2,1:205-218.
    [29] CASADIO M.Control of adipocyte senescence.Nat Cell Biol, 2,4(5):601.
    [30] DONATO A J, MORGAN R G, WALKER A E, et al.Cellular and molecular biology of aging endothelial cells.J Mol Cell Cardiol, 5,9(Pt B):122-135.
    [31] BELLEZZA I, GIAMBANCO I, MINELLI A, et al.Nrf2-Keap1 signaling in oxidative and reductive stress.Biochim Biophys Acta Mol Cell Res, 8,5(5):721-733.
    [32] HAYASHI T, MATSUI-HIRAI H, MIYAZAKI-AKITA A, et al.Endothelial cellular senescence is inhibited by nitric oxide:implications in atherosclerosis associated with menopause and diabetes.Proc Natl Acad Sci U S A, 6,3(45):17018-17023.
    [33] GIULIANI A, PRATTICHIZZO F, MICOLUCCI L, et al.Mitochondrial (Dys) function in inflammaging:do MitomiRs influence the energetic, oxidative, and inflammatory status of senescent cells?.Mediators Inflamm, 7,7:2309034.
    [34] ANERILLAS C, MAZAN-MAMCZARZ K, HERMAN A B, et al.The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress.Nat Aging, 3,3(10):1237-1250.
    [35] EL MA M, MARZULLO M, DE CASTRO I P, et al.Opposing p53 and mTOR/AKT promote an in vivo Switch from apoptosis to senescence upon telomere shortening in zebrafish.Elife, 0,9:e54935.
    [36] LEE O H, WOO Y M, MOON S, et al.Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression.Aging (Albany NY), 0,2(21):20946-20967.
    [37] DEEPIKA, MAURYA P K.Health benefits of quercetin in age-related diseases.Mol, 2,7(8):2498.
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

LIU Chen, CHENG Jiao, LIU Ye, SUN Hui, WEI Xing. Endothelial cell senescence and vascular dysfunction[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(10):916-920.

Copy
Share
Article Metrics
  • Abstract:197
  • PDF: 402
  • HTML: 0
  • Cited by: 0
History
  • Received:December 25,2023
  • Revised:March 07,2024
  • Online: October 22,2024
Article QR Code

You are the 28011 visitor

Post Code：421001 Fax：0734-8160523

Phone：0734-8160765 E-mail：dmzzbjb@163.net

Editorial Office of Chinese Journal of Arteriosclerosis ® 2025