Research progress of PRDX6 in cardiovascular diseases

Home > Archive>Volume 32, Issue 11, 2024 >932-938

Research progress of PRDX6 in cardiovascular diseases
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                        XIE Rumei1,2XIE Rumei
Fujian Medical University & The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fuzhou, Fujian 350102, China;Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China
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LI Jiakang1,2LI Jiakang
Fujian Medical University & The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fuzhou, Fujian 350102, China;Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China
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YAO Mengge1,2YAO Mengge
Fujian Medical University & The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fuzhou, Fujian 350102, China;Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China
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ZHANG Li1,2ZHANG Li
Fujian Medical University & The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fuzhou, Fujian 350102, China;Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China
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Affiliation:1.Fujian Medical University & The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fuzhou, Fujian 350102, China;2.Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China)
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Abstract:

In the study of cardiovascular diseases, Peroxiredoxin 6 (PRDX6) is the only mammalian 1-Cys member of the Peroxiredoxin (PRDX) family and has attracted much attention. PRDX6 plays a unique role in oxidative stress due to its peroxidase activity and phospholipase A2 activity, and has been shown to participate in redox homeostasis and phospholipid metabolism. In recent years, the role of PRDX6 in the occurrence and development of cardiovascular diseases has received great attention. However, there is no unified understanding of the function of PRDX6 in the cardiovascular system at present. This article aims to briefly summarize the research progress of PRDX6 in cardiovascular diseases such as atherosclerosis, pulmonary hypertension, myocardial infarction, heart failure, abdominal aortic aneurysm, and systematically review the expression changes, mechanism of action, and possible therapeutic potential of PRDX6 in these cardiovascular diseases, hoping to provide new ideas and strategies for cardiovascular diseases intervention.

Key words:Peroxiredoxin 6; cardiovascular disease; oxidative stress; inflammation

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XIE Rumei, LI Jiakang, YAO Mengge, ZHANG Li. Research progress of PRDX6 in cardiovascular diseases[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(11):932-938.

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Received:April 01,2024
Revised:July 23,2024
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Online: November 22,2024
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