- GAO Huimin
GAO Huimin
Hypertension Center, State Key Laboratory of Cardiovascular Disease & National Center for Cardiovascular Diseases, Fuwai Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102300, China
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GENG Bin
Hypertension Center, State Key Laboratory of Cardiovascular Disease & National Center for Cardiovascular Diseases, Fuwai Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102300, China
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Hypertension Center, State Key Laboratory of Cardiovascular Disease & National Center for Cardiovascular Diseases, Fuwai Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 102300, China)
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RNA splicing is an important process for eukaryotes to regulate gene expression. Alternative splicing allows organisms to produce multiple functional RNAs and proteins from a single transcript, thereby expanding the application of genetic information. Moreover, alternative splicing makes it a reality that limited numbers genes can express numerous complex proteins. More and more studies reveal that incorrect splicing is closely associated with human diseases including cardiovascular diseases. This review provides an overview of the definition and mechanism of RNA splicing, as well as the role of alternative splicing in the pathogenesis of atherosclerosis.
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GAO Huimin, GENG Bin. The progress of RNA splicing and splicing factors in the atherogenesis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2025,33(2):93-101.
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History
- Received:March 21,2024
- Revised:May 31,2024
- Online: March 05,2025
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