2025年4月2日 周三
Home > Archive>Volume 33, Issue 2, 2025 >169-177. DOI:10. 20039/ j. cnki. 1007-3949. 2025. 02. 011
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The emerging role of lncRNA-mediated ceRNA regulatory networks in atherosclerosis-associated endothelial dysfunction
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1.Cardiovascular Disease Research Center of Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091,China;2.Cardiovascular Department of Hangzhou Red Cross Hospital, Hangzhou, Zhejiang 310009, China;3.Xiyuan Hospital, School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;4.Health Research Center of Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China)

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R5

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    Abstract:

    Endothelial dysfunction is a pivotal contributor to atherosclerosis (As) pathogenesis. A comprehensive understanding of the mechanisms of endothelial dysfunction would provide novel insights into effective treatment of As. Recent advances in genome and transcripome technology have enabled researchers to further explore the molecular mechanisms of endothelial dysfunction. It has been found that the regulatory network of competitive endogenous RNA (ceRNA) mediated by long non-coding RNA (lncRNA) plays a key role in endothelial dysfunction. lncRNA acts as a “molecular sponge” for microRNA (miRNA) to block the post-transcriptional repression of miRNA on downstream target gene messenger RNA (mRNA) by binding to miRNA, thereby regulating the function and phenotypic conversion of endothelial cell (EC) lncRNA-miRNA-mRNA interactions are widely involved in play an essential role EC inflammatory responses, apoptosis, autophagy, angiogenesis, and endothelial-mesenchymal transition (EndMT). Which suggests that it may be a potential therapeutic targets for As.

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LUO Jinwen, LIU Min, LI Min, YU Yanqiao, SHI Dazhuo, MA Xiaojuan. The emerging role of lncRNA-mediated ceRNA regulatory networks in atherosclerosis-associated endothelial dysfunction[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2025,33(2):169-177.

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History
  • Received:December 26,2023
  • Revised:February 11,2024
  • Online: March 05,2025
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