Abstract:Aim To explore the anti-inflammatory mechanisms of high density lipoprotein （HDL） by observing the effects of apolipoprotein A1 （ApoA1），a major protein component of HDL，on the mouse bone barrow macrophage polarity. Methods Apo A1 （5，10，15 mg/L） were added to the cultured mice marrow-derived macrophages for 24 h.The expression of membrane molecules CD16/32，CD206 were detected using fluorescence activated cell sorting （FACS） Enzyme-linked immunosorbent assay （ELISA） were used to detect the secretion of interleukin-10 （IL-10） and IL-12 Real-time quantitative polymerase chain reaction were used to detect the expression of Toll like receptor 4 （TLR4），myeloid differentiation factor 88 （MyD88），interferon regulatory factor 5 （IRF5） mRNA. Results After incubation mice marrow-derived macrophage with ApoA1 （5，10，15 mg/L） for 24 h，the expression of CD16/32，IL-12 was decreased，expression of CD206，IL-10 expression was elevated，and the expression of TLR4，MyD88，IRF5 mRNA was decreased.Conclusion ApoA1 promote macrophages towards an anti-inflammatory M2 phenotype，which may be responsible for the anti-inflammatory effects of HDL.

Abstract:Aim To discuss the relationship between the changes of endothelial cell function and pathogenesis of arteriosclerosis obliterans （ASO）. Methods ASO models were constructed with the method of high-fat diet plus intimal injury，at 4，8 and 12 weeks after operation，the limb blood perfusion was observed using laser doppler flowmetre，the arterial morphology was observed using light microscopy and transmission electron microscopy，using percoll density gradient centrifugation method to determine the number of circulating endothelial cells （CECs），serum tumor necrosis factor-α （TNF-α），interleukin-1 （IL-1），endothelin-1 （ET-1） and nitric oxide （NO） levels were detected using enzyme linked immunosorbent assay （ELISA） double antibody sandwich assay. Results Rat models of ASO were established successfully，the left limb blood perfusion was significantly decreased after operation，the serum TNF-α，IL-1，ET-1 levels were significantly higher，and the level of NO was significantly less than normal control after operation，and there was significant difference （P<0.01 ）. Conclusions The injury of endothelial cells and its secretory function is the important pathological process of ASO，and protecting vascular endothelial cells，improving endothelial cell secretion function，should be important therapeutic principles in early ASO.

Abstract:Aim To observe the effect of Alisma soup on the expression of matrix metalloproteinase-9 and the correlation with ERK pathway on foam cell derived from rat peritoneal macrophages. Methods Foam cell model derived from rat peritoneal macrophages was established after induction with oxidized low density liprotein （ox-LDL） （50 mg/L） for 24h. The foam cells were intervened with 20% Alisma -containing serum for 24 h. They were stained by oil red O to observe foam cell formation. RT-PCR and Western blot was utilized to detect the expression of MMP-9. p-ERK and ERK protein was detected by Western blot. Results The foam cell model was established sucessfully after the stimulation with ox-LDL（50mg/L）. As compared with the control group，the expression of MMP-9 protein and mRNA in ox-LDL group were elevated. However，after the intervention with 20% Alisma soup-containing serum and U0126,the specific inhibitior of the ERK signaling pathway，the expression of MMP-9 protein and mRNA and P-ERK protein decreased significantly comparing with ox-LDL group. There was no change of ERK expression among groups. Conclusion Pretreating macrophage with ox-LDL can establish foam cell model derived from macrophages. Alisma soup can inhibit the expression of MMP-9 in foam cell，and the mechanism maybe has correlation with ERK signaling pathway.

Abstract:Aim To investigate the biological distribution of ^99mTc-AcTnTMA-Fab in the SD rats with acute myocardial infarction. Methods ^99mTc-AcTnTMA was prepared and the rat model of acute myocardial infarction was built. Then 60 rats were randomized into experimental group，control group and blank group. There were twenty rats in each group. In the experimental group，20 rats with acute myocardial infarction were injected with 0.3 mCi ^99mTc-AcTnTMA-Fab and were killed 2 h，4 h，8 h and 12 h after injection respectively （5 rats）. Blood，liver，spleen，kidney，muscle，colon，lung and heart of each rat were taken and the injected dosage （ID%/g） and the ratio of ID%/g for heart to lung （HLR） was calculated. In the control group，20 rats with acute myocardial infarction were injected with 0.3 mCi ^99mTc-AcTnTMA and were killed with subsequent procedure in the same way as the experimental group. In the blank group，20 normal rats were injected with 0.3 mCi ^99mTc-AcTnTMA-Fab and were killed with subsequent procedure in the same way as the experimental group. Results The value of ID%/g and HLR in the experimental group and the control group were significant higher than those in the blank group，which hinted that acute myocardial infarction could uptake specifically the ^99mTc-AcTnTMA-Fab and ^99mTc-AcTnTMA. The value of ID%/g and HLR in the experimental group was significant higher than those in the control group，which hinted that infarction tissue uptake of ^99mTc-AcTnTMA-Fab was more than^99mTc-AcTnTMA. Conclusions ^99mTc-AcTnTMA-Fab could be a useful tracer of myocardial imaging to diagnose acute myocardial infarction.

Abstract:Aim To evaluate whether the timing of maternal hypoxia during pregnancy influenced cardiac angiotensin converting enzyme （ACE） - angiotensinⅡ （AngⅡ） - angiotensin type 1 receptor （AT₁） in the adult offspring. Methods Pregnant rats were randomly assigned to maternal hypoxia group starting from early period of pregnancy （G1，day 3 to 21 of pregnancy），group starting from middle period of pregnancy （G2，day 9 to 21 of pregnancy），group starting from late period of pregnancy （G3， day 15 to 21 of pregnancy），or control group. There were 6 rats for each group. Rats of maternal hypoxia groups were subjected to hypoxia for 3 hours in low pressure cabin with an oxygen concentration of 10%±1%. The level of cardiac AngⅡ was detected by Enzyme linked immunosorbent assay （ELISA） in the adult male offspring at the age of 3 months and 5 months. The mRNA expression levels of cardiac AT₁，AT₂，collagenⅠand collagen Ⅲ were measured by reverse transcription PCR. The protein levels of cardiac ACE，AT₁，AT₂ and phosphorylated extracellular signal-regulated kinase 1/2 （pERK1/2） were also detected. Results Maternal hypoxia from day 3 to 21，or from day 9 to 21 of pregnancy induced increased expression levels of cardiac ACE and AngⅡ in male offspring at the age of 3 months （all P<0.05）. They also induced increased mRNA expression levels and protein levels of cardiac AT₁ in male offspring at the age of 3 months and 5 months （all P<0.05）. And they lead to decreased mRNA expression level and protein level of cardiac AT₂ in male offspring at the age of 5 months （all P<0.05）. But maternal hypoxia from day 15 to 21 affected the expression of AT₁ and AT₂ only in male offspring at the age of 5 months （all P<0.05）. Maternal hypoxia from day 9 to 21 lead to increased protein levels of cardiac pERK1/2 and increased mRNA expression levels collagenⅠand collagen Ⅲ（all P<0.05）. Maternal hypoxia from day 3 to 21 increased the expression of cardiac pERK1/2，collagenⅠmRNA and collagen Ⅲ mRNA （all P<0.05），but maternal hypoxia from day 15 to 21 didn’t affect the expression of cardiac pERK1/2，collagenⅠmRNA and collagen Ⅲ mRNA （all P>0.05）. Conclusions Hypoxia during pregnancy will lead to the activation of cardiac ACE-AngⅡ-AT1 axis in adult male offspring，which is most obvious when maternal hypoxia starts from day 9 to 21，or from day 9 to 21 of pregnancy，and will lead to the phosphorylation of ERK and cardiac collagen deposition.

Abstract:Aim To clarify the effects of Angelica on Tnfaip8l2，Ahsg and Tlr3 gene of brain in spontaneously hypertensive rats （SHR）. Methods The SHR were divided into Angelica group and model group，week-old Wistar rats was act as control group. Systolic blood pressure was measured in different groups before and after treatment，after 4 weeks，RNA from brain of mice was extracted and gene expressive profile was measured. Results Angelica can reduce blood pressure levels in SHR. Compared with the model group，Tnfaip8l2,Ahsg and Tlr3 gene in Angelica group were up-regulated in gene expression profile which biology process was all related to inhibition of atherosclerosis. Conclusion Angelica has some function of antihypertensive and can regulate the gene expression profile of brain in SHR. Angelica produce marked effect mainly through inhibiting atherosclerosis.

Abstract:Aim To study the relationship between H-type hypertension and cognitive impairment in elderly patients. Methods 150 elderly essential hypertension patients were selected from the Department of Gerontology and Geriatrics of the First Affiliated Hospital of China Medical University between August 2011 and February 2013. According to the plasmatic homocysteine （Hcy） levels the elderly essential hypertension patients were divided into 3 groups （none H-type hypertension group: Hcy＜10 μmol/L 40 patients H-type hypertension group 1:10 μmol/L≤Hcy＜20 μmol/L 60 patients H-type hypertension group 2: Hcy≥20 μmol/L 50 patients）. The mini-mental state examination （MMSE），Montreal cognitive assessment （MoCA） and the activities of daily living （ADL） were used to evaluate the cognitive function. According to the MMSE score and ADL score，the H-type hypertension patients were divided into 3 groups （control group，22 patients mild cognitive impairment （MCI） group，54 patients cognitive impairment （CI） group，34 patients）.Results In comparison to none H-type hypertension group，fasting blood glucose （FBG），postprandial blood glucose （PBG），Hcy and uric acid （UA） levels increased significantly，and MMSE score and ADL score decreased significantly in H-type hypertension group 1 and H-type hypertension group 2. In comparison to H-type hypertension group 1，creatinine （Cr），PBG and Hcy levels increased significantly，and MMSE score and ADL score decreased significantly in H-type hypertension group 2. There is a negative correlation between the score of MoCA and plasmatic Hcy level in elderly H-type hypertension patients. Conclusion Elderly patients with H-type hypertension have higher risk for cognitive impairment，and higher plasma Hcy level，the more severe the cognition impaired.

Abstract:Aim To investigate the peripheral blood of a disintegrin and metalloprotease with a thrombo spondin type 1 motifs 13（ADAMTS-13）levels in the patient with coronary heart disease （CHD） and its correlation with high-sensitive C-reactive protein （hs-CRP），N-terminal natriuretic peptide precursor （NT-proBNP），high-sensitive cardiac troponin（hs-cTn）. Methods 145 cases of patients who underwent coronary angiography were selected as research subjects. They were divided into three groups by coronary angiography: 47 cases of patients with stable angina as SAP 49 cases of patients with acute coronary syndrome（ACS），including 26 cases of unstable angina（UAP） and 23 cases of acute myocardial infarction（AMI） 49 cases of patients with non-coronary heart disease as control group. The bloods of all patients were collected after inhospital，blood of the AMI group was collected again after 10～14 days as recovery period. The ADAMTS-13 levels of all patients were measured with ELISA. Results The ADAMTS-13 level in the ACS group （286.22±21.75 ng/L） was strikingly lower than that in the SAP group （357.47±21.98 ng/L） and the control group（581.85±21.52 ng/L）,but there was no significant difference between the AMI group （256.21±29.43 ng/L） and UAP group（258.55±31.56 ng/L）. The ADAMTS-13 level in the AMI group after 10～14 days was higher than that in the acute stage （619.91±30.80 ng/L vs 256.21±29.43 ng/L）. In the ACS group，the hs-CRP，NT-proBNP，hs-cTn levels were higher than those in control group and the SAP group the LVEF was lower than that in control group and SAP group. The ADAMTS-13 levels had negative correlation with hs-CRP，NT-proBNP and hs-cTn，but had positive correlation with LVEF. Conclusion The ADAMTS-13 levels had close relation to the stability of coronary heart disease，and the combination with serological markers and LVEF could predict the occurrence of thrombotic events in patients with CHD better.

Abstract:Aim To observe the effect of Shenshao oral lotion to blood lipid，hemorrheology，and stent restenosis in patients after percutaneous coronary coronary intervention （PCI）. Methods 1 023 patients with coronary heart disease were recruited into our study. Patients were randomly divided into two groups: conventional therapy group and ShenShao oral lotion taking group. Results The level of LDLC in patients of Shenshao oral lotion group decreased lower than that in conventional group in the same period. The indices of blood rheology in patients of Shenshao oral lotion were decreased lower than that in conventional therapy group. The late stage inner loss of the ShenShao oral lotion group was less than the conventional medicine group （P<0.05）. Conclusion Shenshao oral lotion could effectively prevent restenosis after PCI.

Abstract:Aim To investigate the association of early renal impairment with four arterial stiffness indexes derived from ambulatory blood pressure monitoring （ABPM），and to provide comparison result between parameters in detecting the renal impairment of essential hypertension. Methods The 253 essential hypertensive patients were enrolled.The 24 hours mean pulse pressure （24h PP），pulse pressure index （PPI），ambulatory arterial stiffness index （AASI），symmetrical ambulatory arterial stiffness index （S-AASI），urine microalbumin to creatinine （mA1b/Cr） and estimated glomerular filtration rate （eGFR） were collected. Partial correlations and multiple stepwise regression analysis were performed to confirm the relationship between parameters of ABPM and renal lesion. The predictive power of four arterial stiffness parameters for early renal impairment was accessed by ROC curve. Results Correlation test showed a significant positively relationship of 24h PP，PPI，AASI，S-AASI with mA1b/Cr （r0.470，0.448，0.613 and 0.632 respectively，P<0.05），and eGFR were negatively correlated with them （r－0.308，－0.254，－0.399 and －0.352 respectively，P<0.05）. Multiple linear regression analysis also showed independent correlation in 24h PP，PPI，AASI，S-AASI with eGFR. Area under ROC curve of S-AASI，AASI，24h PP and PPI were 0.692，0.686，0.681 and 0.655 respectively. The accuracy of the diagnosis was medium. The highest sensitivity was observed for S-AASI and PPI was with the highest specificity. Conclusion This study can support the idea that the four arterial stiffness parameters derived from ABPM had the similar ability to estimate hypertensive renal impairment.

Abstract:Aim To evaluate the correlation of the plaque composition，morphology and degree of coronary artery stenosis with the clinical types of coronary heart disease. Methods 35 cases received dual-source CT （DSCT） coronary angiography and intravenous ultrasound （IVUS） examination in one month were collected from March，2008 to October，2010. The patients were divided into acute coronary syndrome （ACS） and stable angina pectoris （SAP） groups，according to clinical standards. Among 35 cases，there were 25 with ACS，10 with SAP. With the IVUS as the reference standard，DSCT was performed to measure the plaque composition and the degree of coronary artery stenosis，and to evaluate remodeling index （RI） and eccentric index （EI） of plaques. Results There were 105 vascular branches in 35 cases，including 59 branches in total of 200 segments with lesion vessels. Evaluable 146 segments with lesion vessels had a good consistency in RI and EI （P>0.05）. There was a significant difference between ACS and SAP groups in the number of lipid and calcified plaques （P<0.05）. The lipid plagues accounted for great proportion in ACS group and calcified plaques in SAP group. There was significant difference between RI and EI of plaque for the two groups （P<0.05）.In 130 stenosed segments，there was no statistic difference in the degree of artery stenosis between ACS and SAP groups（P>0.05）. Conclusion Compared with SAP，most of the segments with ACS are detected to have lipid plaque，eccentric distribution and positive remodeling by DSCT.

Abstract:Aim To investigate the histopathological characteristics of thrombus aspirated during primary percutaneous coronary intervention （PCI） in a consecutive ST-segment elevation myocardial infarction （STEMI） population.Methods Thrombus aspiration during primary PCI was performed in 329 STEMI patients. Thrombus age was classified as fresh （＜1 day），lytic （1-5 days），or organized （＞5 days）. The histopathological findings were related to the clinical，angiographic，and procedural characteristics. Results Thrombus could be aspirated in 234 patients （71%）. Fresh thrombus was found in 133 of 230 patients （58%） compared to 97 patients （42%） with lytic or organized thrombi.Conclusion In 42% of patients thrombus age is older than 24 hours，indicating that plaque disruption and thrombus formation occur significantly earlier than the onset of symptoms in many patients.

Abstract:Aim To evaluate the effect of statin treatment on the arteral elastcity in patients with non-alcoholic fatty live disease（NAFLD）. Methods 135 cases with NAFLD were randomly divided into treatment group （atorvastatin 20 mg+life intervene，n 69） and control group（life intervene,n66），the period of the treatment is a half of one year. Results There were significant decrease in weight，cholesterol-level，the transaminase of live，the degree of fatty liver in two groups and there were significant decrease on brachial-ankle pulse wave velocity （Ba-PWV） in treatment group，no change happened in control group. So the effect of treatment group was superior to control group. Conclusion There is a significant effect of atorvastatin treatment on lipid-lowering，weight loss，improving the degree of fatty liver，reversing the arteral elastcity in patients with NAFLD.

Abstract:Aim To investigate the immunological activity change of regulatory T cells （Treg） and discuss its significance in the outcomes of patients with multiple organ dysfunction syndrome （MODS） and acute cerebral infarction（ACI）.Methods According to the development of ACI，patients were divided into MODS group（n8）and non-MODS group（n22）. The patients with ACI were further divided into non-survival group （n5） and survival group（n25）based on their outcomes. Healthy volunteers were served as normal control（n30）. Peripheral blood samples were collected in patients with ACI and healthy volunteers. The immunomagnetic separation technique was applied to separate and purify CD4⁺CD25⁺Tregs in peripheral blood，and phenotypes（CTLA-4） were analyzed by flow cytometry and the contents of interleukin-10（IL-10） released in the supernatants were determined by ELISA. Results Expression of CTLA-4 and level of IL-10 were significantly increased in patients with ACI compared with normal control group. The expression of CTLA-4 and level of IL-10 in MODS group were much higher than those in non-MODS group （P<0.01）. Among the ACI patients，the expression of CTLA-4 and level of IL-10 in the survival group were obviously lower than those in the non-survival （P<0.05 or P<0.01）. Conclusion After ischemia reperfusion injury of cerebral，expressions of the markers on CD4⁺CD25⁺Tregs surface and secretion of cytokines produced by CD4⁺CD25⁺Tregs show significant difference in patients with MODS development and survival state. CD4⁺CD25⁺Treg may play an important role in the pathogenesis of immunoregulation，MODS and mortality of patients with ACI through secretion of inhibitory cytokines.

Abstract:Aim To investigate the levels of calcium and phosphorus disturbance and intact parathyroid hormone （iPTH） in maintained hemodialysis（HD） patients. Methods The study included 98 patients，who were on haemodialysis treatment for 3～192 months. Patients in a group were subdivided into dialysis age ＜12 months group and 12 months＜dialysis age ＜36 months group and dialysis age ≥36 months group. iPTH level and clinical data were compared among the groups. Results Serum iPTH was significantly higher in dialysis age ≥36 months group than that in dialysis age ＜12 months group and 12 months＜dialysis age ＜36 months group（P<0.05）. iPTH level was significantly lower in diabetic patients with short dialysis age（dialysis age ＜36 months） than that in nondiabetic patients （P<0.05）.

Abstract:Aim To explore the association of －455G/A polymorphisms of β-fibrinogen gene with coronary heart disease. Methods 240 coronary heart disease patients and 240 normal people were involved. －455G/A polymorphisms of β-fibrinogen gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism （PCR-PFLP），and the plasma fibrinogen was determined. Results （1）The frequency of GA/AA genotype and A-allele （45.4% and 25.2%） was significantly higher in coronary heart disease group compared with their controls（26.7% and 15.2%）（P<0.05）. （2）The level of fibrinogen of each genotype in coronary heart disease group was significantly higher than the same genotype of the control group In each group，the level of fibrinogen of patients with GA genotype was significantly higher than those of patients with GG genotype,the level of fibrinogen of patients with AA genotype was significantly higher than those of patients with GA genotype（P<0.05）. Conclusion β-fibrinogen gene －455G/A polymorphism may be related to coronary heart disease，the A-allele may be the risk genetic factor for coronary heart disease，and maybe have contact with coronary heart disease by influencing the level of fibrinogen.

Abstract:Aim To investigate the plasma total cholesterol （TC），triglyceride （TG），high density lipoprotein cholesterol （HDLC），low density lipoprotein cholesterol （LDLC），and non high density lipoprotein cholesterol （nHDLC） levels，lipid layer，risk assessment，treatment recommendations and drug treatment in Kailuan community and provide data for the prevention and treatment of dyslipidemia，and for further prevention and control of cardiovascular and cerebrovascular diseases. Methods From 2010 to 2011，a total of 92967 cases in the Kailuan community were censured，serum TC，TG，LDLC，HDLC were measured at the central laboratory of Kailuan hospital. Lipid layer，assessment of risks，recommendations and drug treatment were given in different gender and age. Results The study included 69488 men and 19228 women from the Kailuan community. The mean fasting plasma lipids were: TC （male 4.93 mmol/L，female 5.00 mmol/L），LDLC （male 2.58 mmol/L，female 2.55 mmol/L），TG （male 1.32 mmol/L，female 1.17 mmol/L），HDLC （male 1.51 mmol/L，female 1.64 mmol/L） ，nHDLC （male 3.42 mmol/L，female 3.36 mmol/L）. Lipids level was higher in female than that of male after the age of 50～59. After adjusted by age and sex，high TC，TG，LDLC prevalence （male 7.48%，20.67%，2.59%，female 9.04%，9.97% and 2.88%） and the prevalence of low HDLC （male 11.52%，female 5.80%） were showed. The proportion of recommended drug treatment was 11.56% in male and 11.98% in female. After the age of 55～59，the proportion of recommended drug treatment were higher in female. In the recommended drug treatment group，only 2.28% male and 2.60% female was taking lipid-lowering drugs. Conclusion Lipids level was high in Kailuan community. According to the guidelines recommend，the proportion of actually taking lipid-lowering drugs was low. The focus group for lipids prevention was female after the age of 55～59.

Abstract:Aim To investigate the relationship between metabolic syndrome （MS） and chronic kidney disease （CKD），components of MS and CKD in the middle aged and elderly health cheakup residents of Wuhu city. Methods24095 residents was investigated in a cross-section study. There were 14616 males and 9479 females with the average age of 51.49±9.16 years old. Height，weight and blood pressure were examined，and morning urine and venous blood samples were taken for urine routine，blood glucose，total cholesterol，high density lipoprotein （HDL），low density lipoprotein （LDL），creatinine and uric acid respectively. Results The prevalence of MS and CKD was 14.1%，8.3% respectively. MS was a significant determinant of CKD （OR＝1.55，95%CI was 1.38～1.74）. In multivariate models，obesity， elevated triglycerides，low HDLC，elevated blood pressure and elevated plasma glucose were associated with an increased odds ratio （95%CI） of CKD: 1.18 （95%CI was 1.06～1.301），1.11 （95%CI was 1.00～1.23），1.27 （95%CI was 1.07～1.52），1.31 （95%CI was 1.19～1.45） and 1.15 （95%CI was 1.02～1.30）. Compared to residents without any components of the MS，the multivarated-adusted odds ratios （95%CI） of CKD were 1.21（95%CI was 1.07～1.38），1.40 （95%CI was 1.23～1.61），1.79 （95%CI was 1.54～2.09 and 2.25 （95%CI was 1.77～2.88） for those with 1，2，3，4 components，respectively. Conclusions The MS was a significant determinant of CKD in the middle aged and elderly health cheakup residents of Wuhu city，especially in the male younger residents. The prevalence of CKD were graded with the number of MS components.

Abstract:The hepatic low-density lipoprotein receptor （LDLR） pathway is essential for clearing circulating LDL and is an important therapeutic target for treating cardiovascular disease. Abundance of the LDLR is subject to both transcriptional and non-transcriptional control. Here，we highlight a new post-transcriptional mechanism for controlling LDLR function via ubiquitination of the receptor by the inducible degrader of the LDLR （Idol）. Idol is a recently identified transcriptional target of the liver X receptors （LXR），acting as an E3-ubiquitin ligase. Idol promotes ubiquitination of the LDLR，thereby marking it for lysosomal degradation. Idol also targets two related lipoprotein receptors，the very low-density lipoprotein receptor and apolipoprotein E receptor 2. Despite several similarities，the Idol and PCSK9 pathways for controlling LDLR abundance seem independent of each other. Recent work has also suggested links between Idol and human LDL levels，thereby highlighting the possible role of Idol in human lipoprotein metabolism.

Abstract:Plasma triglyceride （TG） exists mainly in chylomicron particles and very low density lipoprotein （VLDL）. Triglyceride-rich lipoprotein （TRL） in the body is on behalf of the level of TG in plasma，its metabolic process is affected by some factors such as diet，enzymes，transcription factors，gene mutation and microRNA. Metabolic disorders of TRL will cause high TG level. A large number of epidemiological studies have shown that TG level relates with atherosclerotic cardiovascular disease （CVD） closely. Therefore，this article focuses on the current views on relationship of TG and CVD and its proatherogenic mechanism，in order to make clear the important function and meaning of TG in the development of atherosclerosis and provide a new theoretical basis for the prevention and cure of CVD with TG-lowering therapy.

Abstract:Inflammation plays an important role in atherosclerosis. Myeloperoxidase,a biomarker of activation of neutrophils,is an enzyme that is released from activated neutrophils,monocytes and macrophages. Myeloperoxidase and its oxidase products promote the formation of atherosclerotic,and stimulus to thrombogenecity and unstable plaque. Therefore，myeloperoxidase is closely related with the incidence of acute coronary syndrome. Myeloperoxidase is an early biomarker of acute coronary syndrome,and that can predict the incidence of the major adverse cardiac events.