Abstract:Aim To investigate the effect of interferon-inducible protein 16 (IFI16) siRNA on the proliferation and apoptosis of interferon-α (IFN-α) induction of human brain vascular adventitial fibroblasts (HBVAF). MethodsThe siRNA of IFI16 gene was transfected into HBVAF in vitro. 48 hours after transfection, the cells were exposed to 2×10⁶ U/L IFN-α for 24 h. Cell cycle and apoptosis were analyzed by flow cytometry. The mRNA and protein levels of IFI16 were measured by real-time PCR and Western blot. Results After transfection with IFI16 siRNA, the expression of IFI16 mRNA and protein levels was decreased in HBVAF, and the cell cycle at G/S transition was promoted.Meanwhile, stimulated with IFN-α up-regulated the expression of IFI16 mRNA and protein levels, and inhibited the cell cycle transition at G/S and promoted cells apoptosis in HBVAF. Such effect was restrained by transfection with IFI l6 siRNA into HBVAF. Conclusion IFN-α may inhibit cells proliferation and promote cells apoptosis of HBVAF by up-regulating the expression of IFI16.

Abstract:Aim To estimate the effect of total panax notoginsenosides (TPNS) on expression of interleukin-17A (IL-17A), interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) in apolipoprotein E-knockout (ApoE－/－) mice.Methods ApoE－/－ mice were fed with a high fat, high cholesterol diet containing 15% fat and 0.25% cholesterol. At 20 weeks of age, ApoE－/－ mice were randomized into three groups, the model group, the TPNS low dose group and the TPNS high dose group. Mice in TPNS low dose group were given oral doses of TPNS at 40 mg/kg, once a day for 8 weeks. Mice in TPNS high dose group were given oral doses of TPNS at 120 mg/kg, once a day for 8 weeks. Mice in model group were given an equal volume of distilled water orally. After 8 weeks, blood and aortas were obtained. Serum levels of lipid were analyzed, ratio of plaque area to vessel area and the expression of IL-17A, IL-10 and TNF-α were examined by histological staining and ELISA respectively. Results It was observed in our study that serum levels of lipid, ratio of plaque area to vessel area, and expressions of IL-17A and TNF-α were lower in mice which were given TPNS. Serum total cholesterol, triglyceride and low density lipoprotein cholesterol in model group was 28.2±4.0 mmol/L, 2.08±0.17 mmol/L and 10.0±1.9 mmol/L respectively , which were 16.4±2.2 mmol/L, 1.36±0.23 mmol/L and 5.9±1.2 mmol/L in TPNS high dose group (P＜0.001) and 20.4±1.1 mmol/L (P＜0.05), 1.91±0.25 mmol/L (P＞0.05) and 8.0±0.8 mmol/L (P＜0.05) in TPNS low dose group. The ratio of plaque area to vessel area was 31.3%±5.1% in model group, 14.1%±5.0% in TPNS high dose group and 24.2%±4.9% in TPNS low dose group (P＜0.05). High dose of TPNS could down-regulate the expressions of IL-17A and TNF-α in spleen mononuclearcell(IL-17A 18.1±1.5 vs 22.8±3.1,P＜0.05; TNF-α 18.3±1.2 vs 22.9±0.7, P＜0.001). On the other hand, high dose of TPNS could up-regulate the expression of IL-10 in spleen mononuclearcell (40.9±2.2 vs 36.3±2.8, P＜0.05). Conclusion These results suggest that TPNS could prevent atherosclerosis by lowering serum lipid levels and regulating spleen mononuclearcell IL-17A, IL-10 and TNF-α expression. TPNS may have implications for clinical treatment of atherosclerosis vascular disease.

Abstract:Aim To explore the calcification of renal artery and the activation of BMP2/Smad1/Runx2/Osterix signal pathway in type 2 diabetic nephropathy rats. Methods Forty rats were randomly divided into control group and diabetic nephropathy group (DN group). Type 2 diabetic nephropathy model was established by high sugar and fat diet and streptozotocin (STZ) injection. The calcium content were detected by calcium assay kit in 8,2 and 16 weeks. Calcium depositing in the renal artery was observed by Von Kossa staining. The protein expression of BMP2, Smad1, Runx2 and Osterix were detected with immunohistochemistry. Real-time polymerase chain reaction (RT-PCR) were applied to detect the gene expression levels of BMP2 and Runx2 in the renal artery. Results Contents of blood glucose, blood urea nitrogen(BUN), cystatin C (CysC) and 24 h urinary albumin (24 h UA) of DN group at all time point were much higher than those of control group (P<0.05). Serum creatinine (SCr) of DN group was higher than that of control group since 12th week (P<0.05). The calcium content in DN group were significantly higher than those in control group at each time point (P<0.05). Black granules were found deposited in the renal artery of DN rats in 8 weeks and the black calcium salt was gradually increased with the time passing. No calcium salt was found in control group. Compared with the control group, the protein expression of BMP2/Smad1/Runx2/Osterix signal pathway and the expression of BMP2, Runx2 mRNA in DN group rats were significantly higher. Correlation analysis demonstrated that calcium content was positively correlated with BMP2, Runx2 mRNA(r=0.641, r=0.683,all P<0.01) . Conclusion The renal artery calcification may appear in the early stages of type 2 diabetic nephropathy rats model and the activation of BMP2/Smad1/Runx2/Osterix signal pathway may be an important regulating factor in the renal artery calcification.

Abstract:Aim To observe the protective effects of Angelica sinensis volatile oil (ASVO) on levels of blood lipids and vascular endothelial structure in hyperlipidemia rats. Methods 72 SD rats were randomly assigned to normal control group of 12 and model group of 60. Rats in the model group were fed with high fat diet and 50 mg/kg propylthiouracil by intragastric administration for 4 weeks. The model rats were randomly divided into the model control group, fluvastatin group (0.5 mg/kg), and high-, medium- and low-dosage of ASVO groups (0,0, 15 mg/kg) with 12 rats in each group. After 3 weeks, artery blood was collected and the content of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC) levels and calculated atherosclerosis index (AI) were measured, the contents of endothelin-1(ET-1) in plasma, nitric oxide(NO) in serum and von willebrand factor(vWF) in plasma were measured with enzyme linked immunosorbent assay (ELISA). Thoracic aorta was separated, 10% formalin-fixed and parrffin-embedded, cut into slice, HE stained and the vascular endothelial structure was observed under light endothelial structure. Results Compared with control group, the content of TC, TG and LDLC in plasma significantly increased (P<0.05), the content of ET-1 and vWF in plasma significantly increased, the content of NO in the serum significantly decreased in hyperlipidemia model group (P<0.05). The content of TC and LDLC in plasma significantly decreased (P<0.05), the content of ET-1 and vWF in plasma significantly decreased, the content of NO in the serum significantly increased in the high and medium dosage of ASVO groups (P<0.05), the structure of the vascular endothelial injury were effectively improved in the high and medium dosage of ASVO groups. Conclusion The certain therapeutic effects of Angelica sinensis volatile oil were determinated in hyperlipidemia rats, and the structure of the vascular endothelial injury was improved.

Abstract:Aim To observe the therapeutical effect of atorvastatin taken orally together with antihypertensive medicine on visual electrophysiological changes in patients with hypertensive retinopathy (HR). Methods 238 patients with essential hypertension complicated with retinopathy were enrolled in the study, and were randomly divided into atorvastatin group (132 cases) and the conventional treatment group (106 cases). The patients of two groups were given the same oral antihypertensive medicine. On the basis, the patients in the atorvastatin group were treated with atorvastatin.The changes of flash electroretinogram (FERG) a-wave, b-wave and oscillatory potential (OP) were observed and compared before and after 6,2, 24 months of treatment in the two groups. Results In the two groups, after treatment, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly lower than those before treatment (P＜0.001), FERG a-wave, b-wave, OP and the wavelets latent periods were significantly shortened (P＜0.05 or P＜0.001), the amplitudes were significantly prolonged (P＜0.05 or P＜0.001), and the longer the duration, the greater the difference.Compared with the same period conventional treatment group, blood pressure, blood lipid and body mass index could be effectively controlled in atorvastatin group (P＜0.05 or P＜0.001), but blood pressure decline did not significantly correlate with the lipid-lowering effect (P＞0.05). 12 months after drug use, compared with conventional treatment group, FERG a-wave, b-wave, OP and the wavelets latent periods were significantly shortened (P＜0.05 or P＜0.01), the amplitudes were significantly prolonged (P＜0.05 or P＜0.01) in atorvastatin group, and 24 months after drug use, the above differences were more obvious (P＜0.01 or P＜0.001). Principal component Logistic regression analysis showed that the decrease range of SBP, DBP, total cholesterol, low density lipoprotein cholesterol and the application of atorvastatin were the main factors influencing the improvement of visual electrophysiology in patients with HR (P＜0.05 or P＜0.001). Conclusion Atorvastatin therapy on the basis of conventional anti-hypertensive drugs can obviously improve the effect in the treatment of HR with the improvement of visual electrophysiology.

Abstract:Aim To investigate the illness perception of patients with ischemic stroke, and to analyze its influencing factors. Methods 103 patients with ischemic stroke were investigated by the self-made general situation questionnaire, the Chinese illness perception questionnaire-revised (CIPQ-R), United States National Institute of Health stroke scale (NIHSS) and simplified coping style questionnaire (SCSQ). Survey data were statistically analysed by using single factor variance analysis and multiple linear regression. Results The score of identity dimension in patients with ischemic stroke was 3.11±2.53, the score of consequences dimension was 16.95±4.39, the score of emotional representations dimension was 18.45±5.50. The multiple linear regression analysis indicated that the influencing factors of the illness perception were the age, gender, home address, occupation, and NIHSS score. Conclusion The patients with ischemic stroke have a negative illness perception, and medical staff should improve it by taking targeted interventions according to the main influencing factors.

Abstract:Aim To detect the level of a disintegrin and metalloproteinase with thrombospondin motifs 4(ADAMTS4) and high sensitivity C-reactive protein (hs-CRP) using coronary sinus sampling and to assess the effect of PCI on ADAMTS4 and hs-CRP levels. Methods The 81 subjects were classified according to their coronary angiographic findings into control, simple, and complex groups. PCI was performed in 30 patients. Blood samples were taken from the coronary sinus. ADAMTS4 and hs-CRP levels were measured by ELISA and turbidometry respectively. Results ADAMTS4 showed a higher level in complex group (100.1±41.3 μg/L) than in control (55.9±17.9 μg/L) and simple group (79.5±34.8 μg/L). The ADAMTS4 level showed a positive correlation with the hs-CRP level whether from all patients or from patients with CAD (r₁=0.73, r₂=0.76). The ADAMTS4 value was higher after PCI than before PCI (108.9±39.5 μg/L vs 84.4±35.3 μg/L, P＜0.001), and the same was found regarding hs-CRP (3.1±1.4 mg/L vs 2.6±1.2 mg/L, P＜0.001). Conclusion Coronary ADAMTS4 level elevated in patients with CAD. The increase of ADAMTS4 and hs-CRP levels after PCI might be attributed to their release from the coronary atheroma.

Abstract:Aim To investigate the structure and hemodynamics characteristics of carotid and vertebral artery by ultrasonography in patients with acute cerebral infarction (ACI). Methods Carotid artery and vertebral artery were detected by ultrasonography in 298 patients with ACI and 101 healthy controls. The differences of blood vessel diameter, intima-media thickness (IMT), vascular resistance index (RI) and blood flow velocity were analyzed between the two groups. According to the NIHSS score, the ACI group was divided into two subgroups:progressive ACI group and non-progressive ACI group. The differences of the above ultrasonic parameters were compared between the two subgroups. Results (1)Common carotid artery internal diameter, internal carotid artery internal diameter, common carotid artery RI, left internal carotid artery RI in ACI group were higher than those in healthy control group (P＜0.05). End diastolic velocity (Vd) of common carotid artery, peak systolic velocity (Vs) of internal carotid artery, internal carotid artery Vd, right vertebral artery Vs and Vd in ACI group were lower than those in healthy control group (P＜0.05). (2)Left common carotid artery Vs and RI, internal carotid artery IMT in progressive ACI group were higher than those in non-progressive ACI group (P＜0.05). Right vertebral artery Vs in progressive ACI group was lower than that in non-progressive ACI group (P＜0.05). (3)Pearson correlation analysis showed that age was correlated with various vascular ultrasonic parameters. Conclusions Carotid atherosclerosis vascular structural decompensation is one of ACI characteristics. IMT thickening of the internal carotid artery may be a risk signal of ACI progression.

Abstract:Aim To observe the beneficial effects of high dose atorvastatin sequential treatment on high sensitivity C-reactive protein (hs-CRP) and short-time major adverse cardiovascular events (MACE) in acute non-ST segment elevation myocardial infarction (NSTEMI) patients underwent elective percutaneous coronary intervention (PCI). Methods One hundred patients with NSTEMI from September 2009 to April 2012 underwent elective PCI were randomly divided into two groups:high dose atorvastatin sequential treatment group (group A) and positive control group (group B).All patients were given 80 mg atorvastatin instantly and then 40 mg once a day. One the basis of hydration therapy, group A received additional 40 mg atorvastatin at 6 hours before PCI. Lipid levels and hs-CRP were measured and compared 24 hours and 48 hours post-PCI. 12-week incidence of MACE was done in a follow-up. Results Lipid levels had no significant change after PCI (P＞0.05). In comparison with the levels before PCI, hs-CRP increased significantly in the two groups (P＜0.05), and group A was significantly lower than group B (P＜0.05). The incidence of MACE was similar in the two groups (4% vs. 6%, P＞0.05). The two groups showed no clinically significant liver enzymes and elevated muscle enzymes, and there were not adverse reactions in both groups. Conclusion High dose atorvastatin sequential therapy can be a certain degree of inhibition of endothelial inflammatory response in NSTEMI patients after PCI, and the security is good, but can’t decrease the short-time MACE.

Abstract:Aim To study relevance of essential hypertension (EH) patients with brachial-ankle pulse wave velocity (baPWV), carotid intima-media thickness (cIMT) and homocysteine (Hcy), D-dimer. Methods The study was performed on 246 essential hypertension patients. According to baPWV they were divided into normal group (baPWV＜1700 cm/s) and abnormal group (≥1700 cm/s). According to cIMT they were divided into normal group (cIMT＜0.9 mm), thickening group (0.9 ≤cIMT＜1.2 mm), plaque group (cIMT≥1.2 mm). And Hcy, D-dimer and blood biochemistry were detected. Results Hcy and D-dimer levels in abnormal arterial stiffness group were significantly increased compared with those in normal arterial stiffness group (P＜0.05). Hcy and D-dimer levels in the normal cIMT group, the thickening group, the plaque group were gradually increased. Partial correlation analysis showed that after excluded age, weight, blood lipids and blood glucose, baPWV was positively correlated with Hcy and D-dimer (r＝0.18, r＝0.32, P＜0.05), cIMT was positively correlated with Hcy and D-dimer (r＝0.56, r＝0.27, P＜0.05), BaPWV was positively correlated with cIMT (r＝0.29, P＜0.05). Conclusion The increase of Hcy and D-dimer were correlated with cIMT and baPWV which predicted artery disease.

Abstract:Aim To investigate the associations of methylenetetrahydrofolate reductase(MTHFR)gene C677T polymorphism and levels of plasma homocystein and coronary heart disease. Methods A total of 256 patients admitted in our hospital from 2013 to 2015 were divided into two groups according to age:<60 years group(goung and middle-aged group, n=107) and ≥60 years group (old-aged group, n=149) . We selected 145 healthy controls as control group. The MTHFR gene C677T polymorphism was detected by polymerase chain reaction(PCR) and gene chip technology. The levels of plasma homocystein were detected by high performance liquid chromatography in all groups. We analyzed distribution of the MTHFR gene C677T polymorphism and the levels of plasma homocystein in all groups. Results The frequency of CC(homozygous normal),CT(heterozygous),and TT(homozygous mutant) in group <60 years, ≥60 years, control was individually 26.2%,43.9%,29.9%;35.6%,42.3%,22.1% and 37.9%,40.1%,21.4%. The frequency of control group and T alleles in group <60 years, ≥60 years,control group was individually 48.1%,51.9%;56.8%, 43.2% and 58.3%, 41.7%. There was significant difference in the allele frequency of C677T polymorphism between <60 years group and control group (χ²=5.10,P=0.015). There was no significant difference between ≥60 years group and control group (χ²=0.147,P=0.382). The levels of plasma homocystein in <60 years group were higher than control group. Conclusion There was higher levels of plasma homocystein in TT genotype. There was only associations between the MTHFR gene C677T polymorphism and young and middle-aged CHD patients. There was not relationship in old-aged CHD patients. The higher levels of plasma homocystein and higher T allele frequency maybe were risk factors in young and middle-aged CHD patients. The pathogenesis of CHD was different in different age grades patients.

Abstract:Aim To observe the change of serum Visfatin level in patients with unstable angina (UA); To investigate the correlation between serum Visfatin and soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular cell adhesion molecule-1 (sICAM-1). Methods The changes of serum Visfatin, sVCAM-1 and sICAM-1 levels were detected by using quantitative sandwich enzyme-linked immunosorbent assay in 80 UA patients (UA group), 68 patients with stable angina (SA group) and and 60 healthy subjects (control group). Other clinical biochemical indexes were routinely detected at the same time. In the UA group, the relationships between serum Visfatin and sVCAM-1, sICAM-1, high-sensitivity C-reactive protein (hs-CRP), other biochemical indexes were analysed by Pearson correlation test. Results The levels of serum Visfatin, sVCAM-1 and sICAM-1 in UA group were significantly higher than those in SA group and control group (P＜0.05, P＜0.01). In the UA group, serum Visfatin level was significantly positively correlated with sVCAM-1 (r＝0.332, P＜0.01), sICAM-1 (r＝0.479, P＜0.01), hs-CRP (r＝0.521, P＜0.01), but there was no significant correlation between serum Visfatin and waist circumference, body mass index, blood pressure, other biochemical indexes. There were no significant differences in serum Visfatin, sVCAM-1 and sICAM-1 levels between the SA group and the control group (P＞0.05). Conclusions The level of serum Visfatin is significantly increased, and is positively correlated with sVCAM-1, sICAM-1 and hs-CRP in UA patients. It is suggested that serum Visfatin is closely related to vascular endothelial injury and plaque instability, so it may be a marker of vascular endothelial injury.

Abstract:Aim To investigate the relationship between plasma β2-microglobulin (β2-MG), ankle-brachial index (ABI) and blood pressure variability (BPV) in elderly patients with hypertension. Methods 423 elderly patients with essential hypertension were selected. According to the plasma level of β2-MG, the patients were divided into two groups:β2-MG＜2 mg/L group and β2-MG≥2 mg/L group, and BPV difference was compared between the groups. In addition, according to the ABI value, the patients were divided into two groups:ABI＜0.9 group and ABI≥0.9 group, and the differences of BPV and β2-MG were compared between the groups. Respectively taking 24 h systolic blood pressure variability (24hSBPV) and 24 h diastolic blood pressure variability (24hDBPV) as the dependent variable, other variables as independent variable, the regression models were established by stepwise regression method to analyze the relationship between plasma β2-MG, ABI and BPV. Results 24hSBPV, 24hDBPV and 24 h mean artery blood pressure in β2-MG≥2 mg/L group were significantly higher than those in β2-MG＜2 mg/L group (23.33%±5.12% vs 20.39%±4.74%, 17.10%±4.98% vs 15.40%±4.60%, 94.36±12.33 mmHg vs 90.67±14.52 mmHg, all P＜0.001). 24hSBPV, 24hDBPV and plasma β2-MG level in ABI＜0.9 group were significantly higher than those in ABI≥0.9 group (24.34%±6.02% vs 19.45%±5.49%, 17.27%±5.18% vs 14.62%±4.95%, 2.87±1.20 mg/L vs 1.56±0.85 mg/L, all P＜0.001). Multiple linear regression analysis showed that 24hSBPV was positively correlated with age, plasma β2-MG level and low density lipoprotein, and negatively correlated with ABI, 24hDBPV was positively correlated with age, plasma β2-MG level, and negatively correlated with ABI. Conclusions In elderly patients with hypertension, BPV increases with age. The increase of BPV can aggravate the degree of atherosclerosis, and is closely related to the degree of target organ damage.

Abstract:Aim To study the clinical effect of coronary artery shunt in off-pump coronary artery bypass. Methods 86 cases of off-pump coronary artery bypass grafting were divided into two groups:application of coronary artery shunt group (experimental group, 43 cases) and no application of coronary artery shunt group (control group, 43 cases), creatine kinase-MB isoenzyme (CK-MB), cardiac troponin I (cTnI), and N-terminal pro-brain natriuretic peptide (NT-proBNP) were monitored for 1~3 days after operation, and complication rate, ventilation time, ICU stay time and hospitalization time after operation were recorded . Results All cases were cured. The per capita number of coronary artery bypass grafting was 3~5 in the two groups, the number of coronary artery bypass grafts in the experimental group was 3.6±0.7, the number of coronary artery bypass grafts in the control group was 3.6±0.6, there was no significant difference in the two groups. CK-MB, cTnI, NT-proBNP and complication rate were lower in the experimental group than those in the control group (P＜0.05). The ventilation time, ICU stay time and hospitalization time after operation were significantly shortened in the experimental group (P＜0.05). The left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD) were significantly improved after 1 month, 3 months, and 6 months after operation. Conclusion Coronary artery shunt can significantly reduce myocardial ischemic injury in off-pump coronary artery bypass grafting, and has significant clinical effect on reducing the incidence of perioperative acute myocardial infarction and complication rate. It also has significant clinical effect on the protecting cardiac function and shortening the postoperative recovery time.

Abstract:Aim To investigate the relationship between periostin (PN) level and cardiac function, short-term prognosis in patients with acute ST-segment elevation myocardial infarction (STEAMI) by detecting the levels of PN in patients with STEAMI and non coronary heart disease. Methods From May 2014 to September 4,0 patients with STEAMI who were admitted to the hospital and treated with coronary artery intervention were served as observation group, 36 patients with non coronary heart disease were served as control group. Plasma PN levels and other indicators were detected in the two groups. Patients in the observation group were followed up for 6 months for clinical endpoint events. Data were collected for statistical analysis. Results The PN level in observation group was significantly higher than that in control group (45.43±40.10 mg/L vs 10.25±11.64 mg/L, P＜0.0001). The PN level in observation group was positively correlated with Killip classification (r＝0.531, P＜0.0001) and negatively correlated with LVEF (r＝－0.342, P＜0.05). After 6 months follow-up, the PN level in observation group was positively correlated with the incidences of unstable angina, heart failure, and complex clinical endpoint events (all P＜0.05). Conclusion STEAMI patients with high PN level may indicate a worse left ventricular systolic function, and are more likely to have adverse cardiovascular events within six months after myocardial infarction.

Abstract:Aim To explore the relationship between change of ideal cardiovascular health score (△ICHS) and the ankle-brachial index (ABI) in the elderly population. Methods Through stratified random sampling, a total of 5852 cases were enrolled from 101510 Kailuan Group employees who participated in the health examination in 2006-2007, and among which 5440 individuals met the inclusion criteria. 1 physical examination every 2 years, and ABI was measured by ultrosoud in 2010-2011 examination. Excluding the incomplete data, 4524 cases were included for the final analysis. Ideal cardiovascular health score (ICHS) was performed in the population, according to the 7 cardiovascular health indexes proposed by the American Heart Association. According to the △ICHS of 2006-7,0-2011 examination, the relationship between △ICHS and ABI was analyzed by linear regression and Logistic regression. Results With the △ICHS changed from low to high, △SBP, △DBP, △BMI, △TC and △FBG all decreased (P＜0.05). The proportions of ideal salt habit and physical exercise population significantly increased by about 9.3% and 17.2% respectively, and the proportion of ideal smoking population decreased by about 4.6%. SBP, DBP, BMI, TC and FBG were slightly higher than that in baseline. With the increase of △ICHS, ABI gradually increased (P＜0.05). Linear regression analysis showed that △ICHS was positively related with ABI, and after adjusting for various confounding factors, the △ICHS increased by 1 point, ABI increased by 0.004 (B＝0.004, P＝0.004). Logistic regression analysis showed that after adjusting for various confounding factors, compared with the ICHS reducing group, the ABI abnormality of ICHS invariant group and ICHS elevating group revealed a downward trend. The △ICHS increased by 1 point, abnormal ABI risk reduced by about 21% (OR:0.9,5%CI:0.68-0.91). Conclusions △ICHS is positively correlated with ABI. △ICHS is an independent predictor of atherosclerosis in the elderly population.

Abstract:Aim To estimate the prevalence rate, awareness rate, treatment rate, and control rate of dyslipidemia in Uygur people over 35 years old in Aksu area of Xinjiang. Methods Stratified sampling method was used to select a representative subject of the general population in eight cities of Aksu from April 2012 to June 2014. Results The prevalence rate of dyslipidemia was 53.6%. For women, the prevalence rate of dyslipidemia was higher in older women than that in younger women (53.1% vs. 51.5%, P＝0.024). Among the participants with dyslipidemia, the aware rate, treatment rate, control rate of dyslipidemia were 34.5%, 28.0%, and 16.8%. For the total and 35~54 years old subgroup, the treatment rate of dyslipidemia was significantly higher in women than that in men (for total:30.3% vs. 24.9%, P＝0.004; for 35~54 years subgroup:29.7% vs. 24.2%, P＝0.028). For total subjects, the control rate of dyslipidemia was significantly higher in women than that in men (18.1% vs. 15.0%, P＝0.047). Conclusions Uygur people over 35 years old in Aksu area of Xinjiang have a highly prevalence of dyslipidemia, their awareness rate, treatment rate and control rate of dyslipidemia are low. The treatment rate and control rate of dyslipidemia in men were significantly lower than those in women, we should pay attention to the prevention and treatment of dyslipidemia in men.

Abstract:Naringenin is a kind of naringin aglycone which belongs to flavonoid. Rosaceae, rutaceae and citrus plants are good sources of naringenin. It was found to possess strong anti-inflammatory, antibacterial, antioxidant and anticancer biologic activities. Naringenin was demonstrated to have potential health benefits for the improvement of obesity, hypertension, hyperlipidemia and metabolic syndrome (MS). This review focuses on the related research between naringenin and MS, which might enable the development of novel theoretical basis of MS and its related diseases.

Abstract:Recently,C1q/TNF-related protein-3 (CTRP3) as a member of C1q/tumour necrosis factor-related proteins (CTRP) were found,which plays an important role in glucose and lipid metabolism, atherosclerosis, obesity, hypertension, cardioprotective molecule in the ischemic heart. This review will focus on studying advances of CTRP3 in cardiovascular disease.

Abstract:Apoprotein CⅢ exists in a variety of lipoprotein particles and has a close relationship with human hypertriglyceridemia and caidiovascular disease. The protective effects caused by mutations of apoprotein CⅢ genes even result in benefits of lower cardiovascular risk in some particular group of people. Besides its role of atherogenesis, apoprotein CⅢ also promotes inflammatory and apoptosis, which makes it a new therapeutic target for lowering risk of cardiovascular disease. This article mainly summarizes the atherogenesis and therapeutic prospective of aporotein CⅢ.

Abstract:Monocyte-derived microparticles (MMP) are small bubble-shaped particles released by stressed monocyte. MMP have multiple functions, such as causing endothelia dysfunction, proinflammatory activity and procoagulant activity, which play an important role in the process of the pathology of coronary heart disease. At the same time, some risk factors of coronary heart disease can promote the generation of MMP. Therefore, MMP have the potential to become the new diagnostic criteria and therapeutic targets of coronary heart disease. This paper mainly summarizes new research progress of relationship between MMP and coronary heart disease as well as risk factors.