Abstract:Aim To study the effects of cucurmin on the metabolism of low density lipoprotein and lipoprotein (a). Methods Cucurmin was injected into the body of hedgehogs via the armpit vein 2 minutes before the 125 iodine low density lipoprotein ( 125 ?I-LDL), 125 iodine lipoprotein(a) ( 125 I-Lp(a)), 125 iodine desialylated low density lipoprotein ( 125 I-ds-LDL) or 125 iodine desialylated lipoprotein(a) ( 125 I-ds Lp(a)) were injected. The animals were put to death in 1 hour. The radioactivity of 125 I-LDL, 125 I-Lp(a), 125 I-ds-LDL and 125 I-dsLp(a) in the blood, liver, kidney, spleen, gall and adrenal were measured . Results Experiments showed that the absorption of LDL in liver, adrenal and gall increased 228.1%, 86.7% and 70.3% respectively, but decreased 54.4% in spleen and 25.8% in blood. The effects of cucurmin on Lp(a) were similar to that on LDL. The absorption of Lp(a) in liver and adrenal increased 34.7% and 43.1% respectively, but decreased 34.8% in kidney and 19.2% in blood. The absorption of ds-LDL in liver, kidney, adrenal and blood decreased 15.1%, 43.6%, 68.2% and 31.8% respectively, but increased 31.7% in gall. Cucurmin has slightly effects on the metabolism of ds Lp(a). Conclusion Experiments proved that cucurmin may promote the metabolism of LDL and Lp(a) in liver and adrenal, increase excretion of LDL by gall and inhibit the absorption of LDL in spleen. It make the concentration of LDL and Lp(a) in blood decrease and achieve the effects of lowering lipids and antiatherosclerosis.

Abstract:Aim We used hedgehogs to study the effects of sialic acid in the structure of low density lipoprotein (LDL)and lipoprotein (a)[Lp(a)] on the metabolism of the LDL and Lp(a) with 125 iodine. Methods The end sialic acid on the stucture of LDL and lipoprotein (a) were removd with the treatment of neuraminidase.The desialylated lipoprotein (a) (ds-Lp (a), desialylated low density lipoprotein (ds-LDL),LDL and Lp (a)were marked with 125 iodine tyramine cellobiose. They were injected into the body of the hedge hogs via the armpil vein. The animals were put to death in 3 h and 6 h.The concentration of radioactivity in the blood, liver, spleen,kidney and gall were measured. The change of metabolism of ds-LDL and ds-Lp (a) were analyzed and compared with that of norma LDL and Lp (a). Results The experiments showed that the rate of the metabolism of ds-LDL in 3 h is 7.6% lower than that of LDL,and the rate of the metabolism of ds-LDL in 6 h is 12.23% higher than that of LDL. On the contrary the concentrations of ds-Lp (a) in all the organs reduced by 2 times and 3.85 times to the concentrations of Lp (a)in 3h and 6h respectively,LDL and ds-LDL canbe swallowed by the spleen cells and stored. Although Lp (a) can alsO be swallowed by the spleen cells,ds-LP (a) had a little to enter the spleen cells. Even so it can be removed quickly.Conclusions Experiments proved that sialic acid plays a very important role in the metabolism of Lp (a)and remaining stable of the structure of Lp (a).