Although ultrasonic therapy on the coronary heart disease have been identified as in effect, no studies have evaluated the capability of the ultrasound eliminating atherosclerotic lesions. The purpose of the present study was to elucidate the roles of the ultrasound in the hyperlipedemia reduction and the plaque ablation on the basis of the experimental animal models.Abstract: Methods Thirty Chinese white rabbits were divided into 3 groups: model, natural eliminating and ultrasonic therapeutic group, according the age and the body weight. In every group the experimental hyperlipedemia and atherosclerosis were produced by feding high lipid diets for 110 days. Then model group served as contral to assess on the atherosclerotic lesions, other two groups were given to normal diets maintaining 63 days so as to evalurate the role of ultrasonic plaque ablation. In the therapeutic group ultrasound was irritated every day for 15 min in front of the heart area, using pulsed mode, frequency 800 kHz and intensity 1. 0 W·cm~(-2). At the all experimental process the serum total cholesterol level was measured once every twenty days. At the end of experiment samples from coronary arteries and aortae were taken using different sections. Light sections were stained with hematoxylin-eosin and weigert and examined by light microscopy lesions with point lattice test system. Ultrathin sections were only to qualitative investigation. Results in the experimental handred-tenth days the serum total cholesterol level of the three groups was distinctly higher than that of the beginning of experiment. By the end of experiment the serum total cholesterol level; the incidence of coronary arterial sections with lesion, and the volume density of atherosclerotic lesions of coronary arteries and aortae in the therapeutic groups were 26.01±8. 15 mmol·L~(-1), 7.86%, 36.59%±6. 98%, 7. 95%±13. 16%, respectively. These results were remarkably lower than those of the natural eliminating groups (P=0. 05 ～0.01). Conclutions Our results suggest that the ultrasound has the significant effects to decrease concentrations of the serum total cholesterol and to eliminate the atherosclerotic pleques. This study was provided the theoretical base to treat coronary heart diseases with the ultrasound.