Aim To investigate the effect of glycosylated low density lipoproteins(gLDL)on expression of sis oncogene in human monocyte-macrophagesand its significance in accerelated atherosclerosis associated with diabetes.Methods Total RNA were isolated from monocyte-macrophages which were prepared by density gradient centrifugation from healthy subjects blood,The dot blot hybridizations were performed with digoxin labelling V-sis probes and detected by chemical lu minescence and densitometry scanning,Results The gLDL significantly enhanced the expression of V-sis in cultured human monocytemacrophages.Conclusions The stimulating effects on sis oncogene expression of gLDL contribute to its atherogenic properties, which may be an important machanism for high incidence of atherosclerosis in diabetic patients.