Aim This study was searched for active mechanism of nitrendipine that prevents and treats atheroscle-rosls.Method The experiments were performed in coro-nary arterial rings of Porcine. Results Nitrendipine inhibited proliferation of cul-tured vascular smooth muscle cell witb M IT colori-nelrc assay in porcine.Chadusio.s Nitrendipine may play an important role on antiatherosclerosis