Aim: Observing the effects of API0134 on the changes of the platelet aggregation, thrombelastogram (TEG ) and blood coagulation in experimental atherosclerotic rabbits.Methods: An atherosclerotic rabbits model fed by high cholesterol was established; and the platelet aggregation function,thrombelastogram and blood coagulation function were examined.Results: In model group produced by high cholesterol fed supplemented with injection of bovineserum albumin reflecting hypercoagulative state and suppressed fibrinolytic capacity showing enhanced platelet aggregation induced by platelet activating factor (PAF);shortened r and k values,and increased ma and E values seen in TEG; markedly reduced activated partial thromboplastin time (APTT) and prologed euglobulinlysis time (ELT ). Whereas ln those group after the establishment of atherosclerotic model with successlve feeding of API0134 for three days showed rnuch improved coagulative and fibrinolytic parameters returning almost to normal.Conclusion: These findings indicate that the API0134 possess the effect of anti-platelet aggregation and anti-thrombus formation contributing to the explanation of one of the mechenism of antiatherosclerosis.