Aim: Researching the relationship between heart function and insulin resistance (IR) in acute myocardial infarction (AMI).Methods: The study included 20 healthy subjects and 26 AMI patients. Oral glucose tolerance test,insulin and Cpeptide release tests were conducted in all subjects. All the patients underwent Doppler echocardiography by which left ventricular systolic and diastolic functional parameters were determined.The subjects were divided into three groups, that is,LEF group (the patients having ejection fraction (EF) <0.05), NEF group(the patients having EF > 0. 05) and normal group.Results: Fasting blood glucose levels were not significantly different among the three groups, whereas fasting insulin levels were increased in order of the groups. In LEF and NEF groups, impaired glucose tolerance coexisted with exceptional strong insulin response to glucose load. and the response in LEF group was stronger than that in NEF group. EF and some other systolic functional parameters were significantly correlated with many of IR parameters.Conclusion: The impaired left ventricular systolic function in AMI patients might be associated with the severity of IR.