Aim: Observing the effect of seal oil on serumlipid, liver-lipid and heart-lipid in rabbits.Methods: A hyperlipemia model of rabbits fed on a diet of high cholesterol and fat was established.Results: Seal oil decreased serum triglyceride and total cholesterol, increased high density lipoprotein cholesterol in hyperlipemia rabbits. Total cholesterol of liver and heart in rabbits received seal oil was lowered significantly.Conclusion: Seal oil play a role in reducing serum lipid and preventing lipid deposition in the liver and heart of rabbits.