红细胞膜Na~+-K~+-ATP酶活性与动脉硬化性脑梗塞的关系
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Relationship between the Activity ofNa ~+-K~+ -ATPase on Erythrocyte Membrane and Arteriosclerotic Cerebral Infarction
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    摘要:

    为探讨红细胞膜Na+-K+-ATP酶活性与动脉硬化性脑梗塞的关系,本文检测了37例动脉硬化性脑梗塞患者、20例脑动脉硬化症患者和25例健康对照者的红细胞膜Na+-K+-ATP酶活性,并将酶活性与脑CT梗塞灶大小进行直线回归分析。结果发现,动脉硬化性脑梗塞和脑动脉硬化症患者的Na+-K+-ATP酶活性明显降低,酶活性降低程度与脑CT梗塞灶大小呈显著负相关性(r=-0.58,P<0.01)。提示:红细胞膜Na+-K+-ATP酶活性降低在动脉硬化性脑梗塞的发病与发展中具有一定作用,它可能是脑梗塞的一个危险因素。

    Abstract:

    To study the correlation between the activity of Na+-K+ -ATPase on erythrocyte membrane and arteriosclerotic cerebral infarction. Activity of Na+-K+ -ATPase on erythrocyte membrane was determined in 37 cases of arteriosclerotic cerebral infarction (ACI)and 25 normal control subjects. Activity of Na+ -K+-ATPase on erythrocyte membrane in ACI was obviously lower than that of control (P<0. 001), and the activity of Na+ -K+ -ATPase on erythrocyte membrane was negative correlated with infarct size on brain CT scans in ACI(r= -0. 58, P<0. 01).It suggested that the reduced activity of Na+ -K +-ATPase on erythrocyte membrane may have some ef-fect in the development of ACI.

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李智文,许国英,卓孝福,吴秀丽.红细胞膜Na~+-K~+-ATP酶活性与动脉硬化性脑梗塞的关系[J].中国动脉硬化杂志,1998,6(3):243~245.

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  • 收稿日期:1998-05-10
  • 最后修改日期:1998-07-31
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