Aim The present study was to compare the lipid lowering efficacy of Luozhida (lovastatin) with zocor (simvastatin). Methods 63 subjects were randomized into two groups: 31 subjects in luozhida group, 32 subjects in zocor group as controls.Blood lipid levels were determined prior to lipid lowering treatment and at the end of 4 and 8 week treatment respectively. Results At the end of 8 week treatment, levels of TC, LDLC and apolipoprotein B in luozhida group and zocor group significantly reduced (P<0.01). The LDL cholesterol lowering efficacy of luozhida was significantly weaker than that of zocor. TG level was also significantly lower after treatment compared with that prior to treatment in both groups (P<0.05). At the end of 8 week treatment HDLC level tended to be higher in both group, though the difference was not statistically significant, while apolipoprotein AI level obviously increased in the luozhida group. There was no obvious side effects during the period of luozhida and zocor treatment and the patient’s tolerance was good. Conclusion Luozhida, as a domestically made lipid lowering drug,is effective for the treatment of hypercholesterolemia.