Aim [WT5”BZ]To investigate the antiatherogenetic effect of Chinese medicine angelica injection and its mechanisms. [WT5”HZ]Methods [WT5”BZ]Atherosclerotic rabbit models were duplicated by feeding high lipid forage. Eighteen rabbits were divided randomly into three groups: control group (Control), model group (Model) and angelica group (Angelica). Common forage (control group), high lipid forage (model group) and high lipid forage adding angelica injection (angelica group)were given to each group accordingly. At the end of the tenth week, blood samples were obtained through carotid artery intubation for detection of serum lipids and malonyldialdehyde (MDA). Thoracic aorta were prepared for measurement of plaque area. [WT5”HZ]Results [WT5”BZ](1) Serum lipids level of model group and angelica group were significantly higher than those of control group (P<0.01). Apart from TG which was different (P<0.01), there was no difference of TC, HDLC, and LDLC between model group and angelica group. (2) Plaque area of model group was larger than that of angelica group (P<0.01). (3)There was significant difference of plasma MDA between any two groups (P<0.01). [WT5”HZ]Conclusions [WT5”BZ]Angelica can inhibit atherogenesis. The mechanisms maybe correlate with its decreasing serum TG and antilipoperioxide action.