Aim To determine the serum CETP concentration in 1 128 healthy Chinese subjects, and to analyze the characteristics of CETP level and distribution in different age and sex groups. Methods The CETP concentration was determined using “Sandwich” ELISA. Results The CETP level was 1.84±1.55 mg/L. The frequency distribution of CETP in healthy subjects was markedly skewed to low concentration. The frequency distribution of CETP in female was significantly higher than that in male (2.40±1.65 mg/L vs. 1.49±1.37 mg/L,P<0.001). There was a highly inverse correlation between the CETP level and age (r=-0.19,P<0.001), while no relation was found between CETP level and lipids concentration. Conclusion The regular pattern of serum CETP in 1 128 healthy Chinese subjects has been demonstrated.