Aim To investigate effects of potassium magnesium aspartate(Panangin) on insulin resistance (IR) in essential hypertention (EH). Methods Fifty-eight patients with essential hypertention were divided into two groups. Panangin group consisted of 30 patients, each taking 6 panangin and 5 mg felodipine a day. Felodipine group included 28 cases, each only taking felodipine for 3 months. Serum glucose (SG), insulin (INS), insulin sensitive index (ISI) and other metabolic parameters were determined. Results ISI and HDLC/LDLC in Panangin group were significantly elevated after treatment respectively comparing with before treatment and Felodipine group, and triglyceride (TG) were reduced. Conclusion Panangin might reduce IR and adjest lipidemic metabolism in EH.