Aim To study the association of angiotensin Ⅱ type 1 receptor (AT1R) gene A1166/C polymorphisms and coronary heart disease (CHD) and to evaluate the effect of AT1R gene A1166/C polymorphism on plasma lipid levels. Methods By Polymerase chain reaction-Restriction fragment length polym orphism (PCR RFLP) methods, AT1R gene A1166/C genotype of 161 CHD patients and 167 controls were determined. Plasma lipid levels are measured by routine way. Results There are no statistically differences in AT1R genotype AC and AA frequencies between aged CHD patients and controls, also no differences are found in plasma lipid levels. Conclusion AT1R gene A1166/C polymorphism play no role on the occurrence of CHD and has no effects on plasma lipid levels.