Aim To explore the existence of specific oxidized low density lipoprotein(ox LDL) receptor and assay its molecular weight. Method Cross competition studies and ligand blotting were performed for analyzing specific ox LDL receptor. Results As an effective competitor, acetyl LDL(ac LDL) could block the uptake of nonspecific ox LDL. Studies indicated that excess ac LDL(200 mg/L)could only inhibited 24.8% of the association and 77.1% of the degradation of ox LDL. Ligand blotting studies showed that 125 I ox LDL could bind to a protein of 84～97 kDa. The binding of ox LDL to this membrane protein was inhibited completely by the addition of excess unlabeled ox LDL. In contrast, 125 I ac LDL couldn't bind to the 84～97 kDa band. Conclusion Studies showed the existence of specific ox LDL receptor and the molecular weight of this receptor was 84～97 kDa.