Aim To determine the feasibility, safety and clinical significance of selective renal angiography in patients undergoing coronary angiography. Methods From July 2001 to August 2002, selective renal angiography was performed in 847 patients immediately after coronary angiography (CAG) to screen for renal artery stenosis (RAS). Clinical characteristics, procedural complications, degree of RAS were recorded for further analysis. 155 patients were chosen randomly to test the serum creatinine before and after the procedure. Results The procedure was accomplished with high success rate (99.6%) and without significant change of serum creatinine (77±11 μmol/L before vs 78±5 μmol/L after,p>0.05). The overall prevalence of RAS was 19% (including 7.1% with obvious stenostic lesion, stenosis above 50%; 3.9% with bilateral obvious stenosis). Multivariate analysis indicated the prevalence of RAS was strongly related to advanced age (>70 years), hypertension and multi vessel coronary artery disease. Conclusions Selective renal angiography immediately after coronary angiography is feasible and safe, and it exerts great significance of detection of RAS.