Aim The evaluation of the clinical feasibility of disruption of intracoronary plaques was conducted by angioplasty with high intensity, low frequency ultrasound. Methods 30 cases of coronary heart disease with stenosis ≥75% in one blood vessel were divided into Ultrasonic dissolved group and PTCA group randomly. Comparison of stenosis degree and ST segment in routine ECG and exercise tests before and after the treatment were conducted. Results Ultrasound was found to have dissolved atherosclerotic plaques in 15 cases. The residual stenosis was 43.0%±15.5% after the treatment, representing a decrease of 43.5%±17.7% compared with that before the treatment (40.1%±15.3% vs 84.7%±4.7%,p<0.05). In 5 out of these 15 patients, the residual stenosis was less than 30%. ST segment in ECG was markedly lifted up after the treatment in 15 patients. There were remarkable differences between the time needed for exercise-induced angina pectoris, the time for exercise-induced decrease in ST segment for 0.1 mV and the maximal range of decrease in ST segment before and those after the treatment (p<0.01). The residual stenosis was significantly more severe in ultrasonic group compared with PTCA group(43.0±15.5% vs 20.9±2.9%, p<0.01). Conclusions Angioplasty with high intensity, low frequency ultrasound can be used as a new approach for treating serious stenosis and improving blood flow of the coronary artery.