Aim To explore the effects of Li Shui Tiao Zhi Capsule (LSTZ) on monocyte chemoattractant protein-1 (MCP-1) of vascular smooth muscle cells (VSMC) and P-selectin of vascular endothelial cells (EC) induced by minilly modified low density lipoprotein (mm-LDL). Methods Cells were treated by different concentrations of serum-containing LSTZ (5%,10% and 20%) and mm-LDL. MCP-1 of VSMC was determined with ELISA. P-selectin of EC was detected with Cell-ELISA. Results The expression of MCP-1 induced by mm-LDL (20 mg/L) can be reduced by 20% serum-containing LSTZ (p<0.05). The expression of P-selectin induced by mm-LDL (40 mg/L) was suppressed by 10% serum-containing LSTZ (p<0.05), and it showed a notably inhibition on concentration of 20% (p<0.01). Conclusions Protecting vascular cell and relieving respone of inflammation may be one of the mechanisms of anti-atherosclerosis of LSTZ. Not only MCP-1 but also P-selectin may be involved in the “XUEYUZHENG" in Chinese Medical theory.