Aim To detect the secretion of different adipose tissue and observe the effect of angiotensin Ⅱ and statin on release of interleukin-6(IL-6) and type-Ⅰ-plasminogen-activator-inhibitor(PAI-1) from human adipose tissue. Methods The human omental and subcutanoems adipose tissues were cultured. The concentration of IL-6 and PAI-1 in media were measured by enzyme-linked immunosorbent assay(ELISA). Results IL-6 released from omental adipose tissue (1 653±339 pg/g tissue) was higher than that from subcutaneous adipose tissue (1 163±733 pg/g tissue, p<0.01), PAI-1 released from omental adipose tissue (100±30 ng/g tissue) is higher than that from subcutaneous adipose tissue (68±14 ng/g tissue, p<0.01) too. IL-6 released from omental and subcutaneous adipose tissue was postively associated with BMI. (r=0.85, 0.69, respectively, both p<0.01). PAI-1 released from omental and subcutaneous adipose tissue is postively associated with BMI (r=0.63, 0.67 respectively, both p<0.01). Angiotensin increased the release of IL-6 from omental and subcutaneous tissue by 19% and 18%, and that of PAI-1 by 15% and 14%, respectively. Atorvastatin suppressed IL-6 release from omental and subtaneouse adipose tissue by 25% and 21%, and suppressed PAI-1 release from omental and subcutaneous adipose tissue by 17% and 16% respectively. Conclusions Adipose tissue can secrete some kinds of cytokine and substances which are associated with obesity. The effect can be stimulated by angiotension and suppressed by atorvastatin.