Aim To analyze the clinical effect of reperfusion therapies on ST-segment elevation acute myocardial infarction(AMI) during hospitalization and follow-up.Methods Two hundred and eighty-one patients with ST-segment elevation AMI were treated by primary percutaneous coronary intervention(PCI),fibrinolytic, rescue PCI or coronary artery bypass graft(CABG).The clinical and angiographic characteristics were analyzed.Major adverse cardiac events(MACE) were assessed during hospitalization and follow-up period.Results 182,51,34 and 14 patients received primary PCI,fibrinolytic,rescue PCI and CABG respectively.There were no siginificant differences in time from onset of symptom to hospital admission,infarct related artery(IRA),culprit lesion type and stenosis degree among four groups.However,there were siginificant differences in age,diabetic history,time from hospital admission to reperfusion therapy,multivessel diseases and patency rate of IRA among four groups.The incidences of recurrent angina and target vessel revascularization were not different among four groups during in-hospital period,but cardiac mortality was significantly different among four groups during in-hospital period.During follow-up period,there were no significant difference in recurrent angina,myocardial infarction and cardiac death among four groups,but 15 patients suffered from stent restenosis and received revascularization in primary PCI group(p<0.001).Conclusions Reperfusion therapy is a safe and effective therapeutic maneuver for patient with AMI,moreover,primary PCI or emergency CABG may be more preferable in cardiac shock patients.The introduction of drug eluting stents is able to dramatically reduce the rate of in-stent restenosis.