Aim To investigate the value of B-type natriuretic peptide(BNP) in the evaluation of heart function and degree of coronary artery disease in the angina pectoris patients.Methods 68 patients of diagnosed by selected coronary angiography(CAG),including 32 stable angina patients and 36 unstable angina patients,whose heart function was Ⅰ～Ⅳ based on NYHA.The relationship between the level of plasma BNP,which was measured by fluoroimmunoassay,and left ventricular ejection fraction(LVEF),which was detected by color Doppler,and degree of coronary artery lesion,was analysed.Results The level of plasma BNP elevated with the aggravation of the heart disease. It was positively correlated with the degree of coronary artery lesion and degree of heart failure(r=0.82,p<0.05;r=0.68,p<0.05),and negatively with LVEF(r=-0.53,p<0.05).Conclusion The level of plasma BNP is a useful marker for diagnosis of heart failure and coronary artery disease,and has great value for the clinical evaluation of the coronary heart disease.