Aim To investigate the effects of Ramipril on expression of lectinlike oxidized low density lipoprotein receptor-1(LOX-1)in a rabbit model of atherosclerosis. Methods Twenty-four male New Zealand white rabbits were randomly divided into three groups: normal diet group,hypercholesterol diet group and Ramipril-treated group.Expression of lectin-like oxidized low density lipoprotein receptor-1 in a rabbit model of atherosclerosis was detected by immunochemistry and reverse transcription polymerase chain reaction(RT-PCR). Results Expression of LOX-1 in hypercholesterol group significantly increased compared with normal diet group.There was a significant dicrease in expression of LOX-1 in the Ramipril-treated group(p<0.05). Conclusion Ramipril inhibits vascular LOX-1 expression,which may play an important role in prevention of atherosclerosis.