Aim To evaluate the effect of adrenomedullin and tumour necrosis factor-αvariation in the coronary circulation in coronary heart disease patients during percutaneous coronary intervention on restenosis. Methods Blood samples of 70 patients with coronary heart disease were obtained from both the coronary sinus and femoral artery before and after angioplasty, immediately after percutaneous transluminal coronary angioplasty. Plasma adrenomedullin, tumour necrosis factor-αlevels were measured by radioimmunoassay. Coronary angiography was performed again at 6 months after percutaneous coronary intervention or having evidents of myocardial ischemia. Results Restenosis occurred in 21.4% (15/70) of patients. Before percutaneous coronary intervention, the adrenomedullin, tumour necrosis factor-αlevels in coronary sinus were no significant differences in patients with or without restenosis. However, adrenomedullin and tumour necrosis factor-αlevels after percutaneous transluminal coronary angioplasty in patients with restenosis (40.1±1.1 pg/L and 15.0±0.4 pg/L) were higher than those without restenosis (35.8±1.6 pg/L and 10.6±0.4 pg/L, all p<0.01). Conclusions There was a high incidence of restenosis in patients with a increasing adrenomedullin、 tumour necrosis factor-αlevels in coronary sinus after percutaneous transluminal coronary angioplasty. It shows that adrenomedullin、tumour necrosis factor-αlevels in coronary sinus after percutaneous transluminal coronary angioplasty have a close relationship with restenosis and may become clinical prognostic indicator of estimating restenosis.