Aim To investigate the effect of Xuezhikang on matrix metalloproteinase-2,9(MMP-2,9)in acute coronary syndromes(ACS) patients. Methods Xuezhikang were administered in thirty ACS patients.MMP-2,9 and pro MMP-2,9 were evaluated before administration,after 7 days and 30 days by SDS-PAGE enzymograph.The normal control group included twenty-five volunteers. Results Serum MMP-2 and pro MMP-2 elevated significantly in ACS group compared with control group(p<0.01).No differences in MMP-2,9 and pro MMP-2,9 existed before administration and after 7 days in patients with ACS.Serum MMP-2 after 30 days in ACS patients elevated significantly than that before administration(p<0.05). Conclusions Serum MMP-2 and pro MMP-2 elevated significantly in ACS patients and Xuezhikang could decrease the levels of serum MMP-2 and pro MMP-2.