Aim Analysis on lipoprotein and apolipoprotein measurement changes caused by coronary angiography(CAG),percutaneous transluminal coronary angioplasty(PTCA),and coronary stent inplantation(PTCA +STENT). Methods We have measured serum lipid and apolipoprotein concentrations against 119 patients(77 males and 42 females)before and after catheterization. Results Significant lipoprotein and apolipoprotein concentration changes were observed before cardiac catheterization vs.after cardiac catheterization.After cardiac catheterization,the average values of TC,TG,LDL-C,and apolipoproteinB decreased by 10.1%,30.7%,13.5%,and 19.1% respectively,and obvious decreases in PTCA and STENT groups when compared to CAG group.However,changes in HDL-C and apolipoprotein A1 were not significant. Conclusions It was observed that heparin has more influence on the apolipoprotein in the blood measurement results;there seems to be a positive correlation between the dosage of heparin and the measurement result.In order to get the actual base data,it is highly recommended that we examine the lipoprotein and apolipoprotein data before conducting any CAG,PTCA,or PTCA +STENT surgeries.