Aim Discuss the effection of Qingxuankeli on rat's aorta pathology morphology and nuclear factor (NF-κB), plateled derived growth factor (PDGF-B), basic fibroblast growth factor (bFGF) positive expression. Methods Choose 50 Wistar rat,assign to normal group (feed basic fodder), model group (feed high fat fodder), high dosage Qingxuankeli group (feed high fat fodder), low dosage Qingxuankeli group (feed high fat fodder), ginkgo blade group (feed high fat fodder). After the 8 weeks, distilled water, high dosage Qingxuankeli, low dosage Qingxuankeli, liquid of ginkgo blade was irrigated into stomach separately for 4 weeks in succession. Examine rat's aorta pathology morphology and NF-κB,PDGF-B,bFGF positive expression. Results The degree of aorta scleratheroma pathological change of high, low dosage Qingxuankeli group, ginkgo blade group is slighter than model group obviously . Compared with the model group,the ratio of plaquearea to aortic cavity area(respectively 21.7±9.9, 1.96±1.62, 4.25±3.01, 5.11±2.82), the NF-κB (respectively 25.5±4.2, 10.53±7.09, 16.67±5.56, 17.18±6.63,p<0.01), PDGF-B (respectively 25.2±8.8, 8.32±5.17, 12.76±4.38, 13.32±5.16,p<0.01), bFGF (respectively 9.99±1.63, 1.41±1.77, 4.71±3.90, 5.00±2.47,p<0.01) positive cell's percentage of aorta of the high, low dosage Qingxuankeli group, ginkgo blade group is reduced, the percentage of high dosage Qingxuankeli group is lower than ginkgoes blade group (p<0.05). Conclusion The function of preventing and curing scleratheroma of Qingxuankeli is related to the fact that Qingxuankeli suppress NF-κB, PDGF-B, and bFGF to express positively.