Aim To assess the outcomes after percutaneous renal artery stent implantation in diabetic patients with renal artery stenosis. Methods Forty-three patients with diabetes mellitus (DM) and severe uni-or bi-lateral renal artery stenosis (luminal diameter narrowing ≥70%) and receiving renal stent implantation were included (DM group), and another 43 non-diabetic patients undergone renal artery stenting were served as controls. Basic characteristics and the changes in blood pressure and renal function including serum creatinine level, urine β₂ micro-globulin (β₂-MG) concentration and assessed glomerular filtration rate were compared between two groups at baseline state and at 6 months' follow-up. Results Before stenting procedure, patients in DM group had higher serum creatinine (135±17 μmol/L vs 107±31 μmol/L, p<0.05) and urine β₂-MG levels (175±72 μg/L vs 139±57 μg/L,p<0.05). And 31 renal arteries with lumen stenosis ≥70% were stented in the DM group, compared with 39 stents in the control group, and the procedural success rate was 100%. At 6 months' follow-up, creatinine level was decreased in both groups, but remains higher in DM group compared with the control (127±31 μmol/L vs 99±22 μmol/L,p<0.05). In DM group the urine β₂-MG was significantly decreased after procedure (134±17 μg/L vs 175±72 μg/L, p<0.05). Despite conventional medical treatment, blood pressure remains poorly controlled in majority of patients (benefit is 44% in DM vs 71% in control,p<0.05). Conclusion Diabetic patients receiving renal artery stenting had a worse prognosis with respect to renal function improvement and blood pressure control than non-diabetic patients.