Aim To observe the effects of medium chain triglyceride(MCT) on obesity and inflammatory reaction in type 2 diabetics mellitus(T2DM).MethodsWith total energy and fat consumption controlled,MCT group's patients took 100% MCT oil,MCT+long chain triglyceride(LCT) group's patients took 50% MCT oil+50% LCT oil and LCT group's patients took 100% LCT oil for 12 weeks.Blood Adiponectin and monocyte chemoattractant protein 1(MCP-1),mRNA expression of peroxisome proliferator activated receptor γ(PPARγ) in peripheral blood mononuclear cell were detected,body height,body weight,waistline and hipline were measured at 0,6 and 12 week.Then body mass index(BMI) and waist-hip ratio(WHR) were analyzed.ResultsCompared with LCT group,body weight,BMI and waistlines of 6 and 12 week in MCT and MCT+LCT groups were decreased and WHR of 12 week in MCT group was much decreased.Compared with LCT group,plasma adiponectin of 6 week in MCT and MCT+LCT groups were higher,plasma adiponectin of 12 week in MCT+LCT group were higher.Compared with LCT group,plasma MCP-1 of 6 wk in MCT group was lower.ConclusionsWith total energy and fat consumption controlled,the daily diet oil is replaced full or partly by MCT,the body weight and WHR decrease and the inflammatory reaction ameliorate in T2DM patients.So MCT possibly help to reduce atherosclerosis risk.