Aim To seek the feasibility of quantity coronary sinus flow for estimation the left coronary stenosis influlence to coronary sinus flow by holdgrip exercise echocardiorgraphy.MethodsCoronary sinus flow velocity recordings before and after holdgrip exercise echocardiography were measured.116 patients accepted coronary angiography,of which 65 had stenosis,51 were normal.The grade of stenosis was estimated by Gensini index.The correlation between the coronary sinus flow and the Gensini index were analyzed.ResultsThe peak systolic flow velocity and peak dilatic flow velocity of coronary stenosis were significantly lower than the normal angiography(51.33±5.60 cm/s vs 71.88±5.64 cm/s,42.37±7.04 cm/s vs 55.18±6.01 cm/s,p<0.05).Coronary sinus index reserve(CSIR) and coronary sinus velocity reserve(CSVR) in coronary stenosis group were lower than those in the normal angiography(1.35±0.12 vs 1.61±0.22,1.49±0.18 vs 1.96±0.44,p<0.05).CSVR had a significant negative correlation with the Gensini index(r=-0.76,p<0.01).ConclusionsCoronary sinus flow measurement by transthoracic echocardiorgraphy can be used for estimating the coronary stenosis.