Aim To Find the relationship between the 12-lead resting electrocardiograph(ECG)features and multiple-vessel coronary artery disease,and evaluate the value of 12-lead resting ECG on predicting multiple-vessel coronary heart disease.Methods ECG and coronary angiography(CAG)of 104 patients were analyzed.All patients were divided into negative group(8 patients),multiple-vessel disease group(30 patients),non-multiple-vessel disease group(66 patients).ST-segment elevation in lead aVR,the number of leads with abnormal ST segment,the sum of absolute ST-segment deviation value,the sum of absolute ST-segment deviation value plus the number of leads with abnormal ST segment,and ST segment time were analyzed among the three groups.The indexes combining with the results of CAG were analyzed.The ECG score method consisted of age and the ECG indexes.Each index reached the provisions as 1 score.We defined the sum of each index as the patient's integrated ECG aggregate score and 4 score was the diagnostic cutpoint.Results There were significant difference between non-multiple-vessel disease group and multiple-vessel disease group for the ECG indexes and age.There are significant differences among the three groups for the integrated ECG aggregate score(p<0.01).Integrated ECG aggregate score was positively related to the number of narrowed coronary arteries(r=0.491,P=0.000).The sensitivity and specificity of the integrated ECG score method were 83%,77% respectively.Conclusion The integrated ECG score method plays an important role in distinguishing multiple-vessel disease of coronary heart disease.