Aim To investigate the changes and the clinical significances of blood lipids in patients with systemic lupus erythematosus(SLE).Methods Retrospective analysis was done on the changes of blood lipids in 85 SLE patients who hadn't been treated with steroid,56 SLE patients who had been treated with steroid and 60 healthy individials.Results The level of triglyceride(TG),total cholesterol(TC) and low density lipoprotein cholesterol(LDLC) were higher in SLE patients who had been treated with steroid than that of control and that of SLE patients who hadn't been treated with steroid(p<0.05),but had no significant difference between SLE patients who hadn't been treated with steroid and control(p>0.05).The level of blood lipids was abnormal in 51.8%(44/85) of the patients who hadn't been treated with steroid,and in 22/25 patients who had renal involvement.It had significant difference between SLE patients who had renal involvement and control(p<0.01).Conclusions The levels of blood lipids were abnormal in SLE patients.It is associated with renal involvement and high dose corticosteroids.The measurement of blood lipids is important for the patient with SLE to prevent and treat the complication of the disease of high blood lipids.