Aim To investigate the relationship of the concentration of serum resistin and insulin resistance in the elderly hypertension patients. Methods The patients (the young 41,the old 43) were divided into hypertension group and normal group. The concentration of fasting serum resistin was detected by enzyme linked immunosorbent assay (ELISA), fasting blood sugar and insulin, serum lipid, and insulin sensitive index (ISI) were determined too, at the same time, waist circumstance,hip circumstance and waist haunch ratio (WHR) of the people involved were measured. Results The concentration of fasting serum resistin was significantly higher in the elder group than that in control group (p<0.05). There was no difference of serum resistin between the hypertension group and normal blood pressure group in the elder patients, and it was little higher in hypertension group than that of normal blood pressure in the control group but the difference was not significant (p>0.05). Plasma resistin was positively correlated with age (r=0.31,p<0.01;r=0.28, p<0.05). The concentration of fasting serum resistin was positively correlated with body mass index (BMI) (r=0.23,p<0.05), negatively correlated with ISI (r=-0.31,p<0.05). But there were no significance between the concentration of resistin and BMI among the test groups. BMI, WHR, blood pressure, serum lipid, fasting serum sugar and insulin was not found to be related to the concentration of serum resistin. Conclusion Fasting plasma resistin was positively associated with age and BMI, but negatively associated with ISI.