Aim To investigate the relationship between glucose fluctuation and subclinical atherosclerosis(As)in type 2 diabetic patients.Methods A random-controlled study was used,170 type 2 diabetic patients(35～70 year-old,duration≤1 year)without As were randomly divided into 4 groups:group A,B,C and D.Each group was given different treatment.All patients accepted following-up once a month.Fasting blood sugar(FBS)and postprandial blood sugar(PBS)were measured after breakfast each time.Other metabolic variables were measured,including body mass index,waist circumference,glycosylated hemoglobin,plasma lipid,ultrasound measurement of the carotid and femoral artery intimal-medial thickness and plaque.Results Over three-year follow-up,data of four groups show no statistical difference in blood glucose fluctuation.Following blood glucose variation intensify,the morbidity of subclinical As increase.Logistic regression analysis show that the risk factors related to subclinical As are smoking,hyperlipemia history,age,WHR and PFSD.Conclusions The instable margin of PBS and FBS may be one of risk factors to subclinic atherosclerosis development in type 2 diabetic patiants.Smoking and hyperlipemia history,age,waist-to-hip ratio are all risk factors to subclinic atherosclerosis in type 2 diabetic patients.