Aim To discuss the influencing factors associated with 30 days prognosis of 219 progressive ischemic stroke(PIS) patients,so as to provide theoretical basis for clinical treatment.Methods According to the severity of nervous dysfunction,the prognosis was rated as effective(including full recovery,significant improvement and improvement) and non-effective(including no change, deterioration and death).Related indexes in 219 supratentorial PIS patients were observed.Single factor analysis and multiple factors analysis were done to analyze the relationship between these factors and 30 days prognosis.Results Nutritional support,rehabilitation care,volume of infarction,hemorrhage of postinfarction,age,complications and Barthel index would influence the prognosis of PIS.Conclusion Sufficient nutritional support,early-stage rehabilitation care,lowering of volume of infarction and hemorrhage of postinfarction,prevention of complications are important elements for improving prognosis.