Aim To study the effect of united therapy of probucol(P),clopidogrel(Anti-thrombosis,A) and atorvastatin(statin,S) on Markers of inflammation of rabbit atherogenesis. Methods 36 rabbits were randomized into four groups. One group did not receive treatments and served as control group. Atherosclerosis was induced in the aorta arteries of rabbits by atherogenic diet in the rest groups for 6 weeks. Then,animals were randomized to receive treatment or no treatment. One group of treatment were received atorvastatin,and the other accepted probucol and clopidogre and atorvastatin and killed after 4 weeks. Results Arterial macrophage infiltration was abolished by the treatment of atorvastatin and united group. Vascular cell adhesion molecule-1(VCAM-1) and interleukin-6(IL-6)were significantly diminished in the neointima and the media,and the same were monocyte chemoattractant protein-1(MCP-1). Notedly,there was a more evident effect in united therapy than Atorvastatin in anti-inflammation. Conclusions Atorvastatin and united therapy diminishes the neointimal inflammation in rabbit atherosclerosis model,and the effect of united therapy was more than atorvastatin. This could contribute to the more stabilization of the atherosclerotic plaque,and may be a more meaningful additional prediction for the reduction of acute ischemic events in patients treated with united therapy.