Aim To analyze the reason and the treatment of the complications of percutaneous coronary intervention (PCI). Methods From September 2002 to July 2006, PCI was performed in 566 patients, complications occured in 47 of them, which were retrospectively reviewed. The incidence rate of complications in anterior 283 patients was compared with that in post 283 patients , and the long-term incidence rate of the metal-naked stents was compared with that of rapamycin-coated stents. Results There were 6 no-reflow phenomenons and slow-reflow phenomenons (1.06%), 9 branch occlusion (1.59%), 4 coronary perforation (0.71%), 3 ventricular fibrillations (0.53%), 2 pseudoaneurysm (0.35%), 10 acute or subac thrombosis (1.77%), 1 long-term thrombosis (0.18%), 2 cerebral apoplexy (0.35%). Conclusion Great importance should be attached to precautions before operation. While the operation is on, it must be done properly and after it, the patients should be monitored closely.