Aim To examine the relationship between ankle brachial index and the extent of coronary stenosis and evaluate the value of ankle brachial index to predict the extent of coronary stenosis in Xinjiang Uyghur patients. Methods 114 patients with coronary angiography were examined by ankle brachial index and hemostatic factors evaluation in addition to history collection. Results Ankle brachial index was inversely and significantly associated with Gensini score(r=-0.6941,P<0.001). Ankle brachial index was significantly different in all groups (P=0.000). The corresponding area under the receiver operating characteristic curve was 0.8219,with standard error(Se) = 0.0415,(u= 7.7518,P=0.0000)in ankle brachial index in 3-vessel disease or left main coronary arterial disease. When ankle brachial index≤0.9,it had a relatively high specificity (91.76%) and sensitivity (41.38%) for predicting the presence of 3-vessel disease or left main coronary arterial disease. Conclusion In Xinjiang Uyghur patients,ankle brachial index is inversely and significantly associated with the extent of coronary stenosis,and ankle brachial index≤0.9 has relatively high specificity and sensitivity for predicting the presence of 3-vessel disease or left main coronary arterial disease.