Aim To investigate the clinical features of nephrotic syndrome with pregnancy induced hypertension (NSP) and the relationship between NSP and poor pregnancy outcomes. Methods Clinical data of 35 cases with NSP (NSP group) and 121 cases with other severe pre-eclampsia (control group) were analyzed retrospectively in this hospital during January 1997 to January 2008. Blood pressure,biochemical indicators,birth weight and maternal and fetal complications were compared between the two groups. Results The incidence of NSP was 0.04%. Those in NSP group were taken bad earlier than those in control group in gestation. The incidence of protein-uria in 24-hour,low albumin-emia,abdominal water,renal-function lesion,premature and maternity and fetus complication in NSP group were higher than that in control group significantly (P<0.01),and perinatal mortality in NSP group was higher than that in control group (P<0.05). Conclusions NSP often occurs early in gestation. The perinatal prognosis is poor. Early diagnosis,comprehensive therapy and pregnancy termination in time may decrease the incidence of maternity-fetus complication and improve maternal-fetal prognosis.